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dc.contributor.author채필석-
dc.date.accessioned2019-12-09T17:20:00Z-
dc.date.available2019-12-09T17:20:00Z-
dc.date.issued2018-10-
dc.identifier.citationCHEMBIOCHEM, v. 19, no. 20, page. 2225-2232en_US
dc.identifier.issn1439-4227-
dc.identifier.issn1439-7633-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800388-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/120277-
dc.description.abstractA new family of tandem facial glucosides/maltosides (TFGs/TFMs) for membrane protein manipulation was prepared. The best detergent varied depending on the hydrophobic thickness of the target protein, but ether-based TFMs (TFM-C0E, TFM-C3E, and TFM-C5E) were notable for their ability to confer higher membrane protein stability than the previously developed amide-based TFA-1 (P.S. Chae, K. Gotfryd, J. Pacyna, L.J.W. Miercke, S.G.F. Rasmussen, R.A. Robbins, R.R. Rana, C.J. Loland, B. Kobilka, R. Stroud, B. Byrne, U. Gether, S.H. Gellman, ). Thus, this study not only introduces novel agents with the potential to be used in membrane protein research but also highlights the importance of both the hydrophobic length and linker functionality of the detergent in stabilizing membrane proteins.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grant number 2016R1A2B2011257 to P.S.C.).en_US
dc.language.isoen_USen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.subjectdetergent designen_US
dc.subjectdetergent facialityen_US
dc.subjectamphiphilesen_US
dc.subjectprotein stabilizationen_US
dc.subjectprotein structuresen_US
dc.titleRationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacyen_US
dc.typeArticleen_US
dc.relation.no20-
dc.relation.volume19-
dc.identifier.doi10.1002/cbic.201800388-
dc.relation.page2225-2232-
dc.relation.journalCHEMBIOCHEM-
dc.contributor.googleauthorDas, Manabendra-
dc.contributor.googleauthorDu, Yang-
dc.contributor.googleauthorMortensen, Jonas S.-
dc.contributor.googleauthorHariharan, Parameswaran-
dc.contributor.googleauthorLee, Hyun Sung-
dc.contributor.googleauthorByrne, Bernadette-
dc.contributor.googleauthorLoland, Claus J.-
dc.contributor.googleauthorGuan, Lan-
dc.contributor.googleauthorKobilka, Brian K.-
dc.contributor.googleauthorChae, Pil Seok-
dc.relation.code2018001478-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidpchae-
dc.identifier.orcidhttp://orcid.org/0000-0003-1799-3304-
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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