Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한중수 | - |
dc.date.accessioned | 2019-12-09T16:58:13Z | - |
dc.date.available | 2019-12-09T16:58:13Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v. 50, Article no. 141 | en_US |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://www.nature.com/articles/s12276-018-0165-3 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/120254 | - |
dc.description.abstract | Human endometrium decidualization, a differentiation process involving biochemical and morphological changes, is a prerequisite for embryo implantation and successful pregnancy. Here, we show that the mammalian target of rapamycin (mTOR) is a crucial regulator of 8-bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP)-induced decidualization in human endometrial stromal cells. The level of mSin1 in mTOR complex 2 (mTORC2) and DEPTOR in mTOR complex 1 (mTORC1) decreases during 8-Br-cAMP-induced decidualization, resulting in decreased mTORC2 activity and increased mTORC1 activity. Notably, DEPTOR displacement increases the association between raptor and insulin receptor substrate-1 (IRS-1), facilitating IRS-1 phosphorylation at serine 636/639. Finally, both S473 and T308 phosphorylation of Akt are reduced during decidualization, followed by a decrease in forkhead box O1 (FOXO1) phosphorylation and an increase in the mRNA levels of the decidualization markers prolactin (PRL) and insulin-like growth factor-binding protein-1 (IGFBP-1). Taken together, our findings reveal a critical role for mTOR in decidualization, involving the differential regulation of mTORC1 and mTORC2. | en_US |
dc.description.sponsorship | This work is supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (Ministry of Science and ICT) (NRF-2016R1A2B4015358 & NRF-2018R1A2B6004513) and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health & Welfare (HI17C0426). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | ENDOMETRIAL STROMAL CELLS | en_US |
dc.subject | POSITIVE FEEDBACK LOOP | en_US |
dc.subject | MAMMALIAN TARGET | en_US |
dc.subject | PROGESTERONE-RECEPTOR | en_US |
dc.subject | PHOSPHATIDIC-ACID | en_US |
dc.subject | RAPAMYCIN MTOR | en_US |
dc.subject | CYCLIC-AMP | en_US |
dc.subject | STEM-CELLS | en_US |
dc.subject | CROSS-TALK | en_US |
dc.subject | IN-VITRO | en_US |
dc.title | Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization | en_US |
dc.type | Article | en_US |
dc.relation.volume | 50 | - |
dc.identifier.doi | 10.1038/s12276-018-0165-3 | - |
dc.relation.page | 141-151 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.googleauthor | Baek, Mi-Ock | - |
dc.contributor.googleauthor | Song, Hae-In | - |
dc.contributor.googleauthor | Han, Joong-Soo | - |
dc.contributor.googleauthor | Yoon, Mee-Sup | - |
dc.relation.code | 2018002394 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jshan | - |
dc.identifier.researcherID | P-2072-2015 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-0875-6158 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.