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DC FieldValueLanguage
dc.contributor.author정승준-
dc.date.accessioned2019-12-09T06:51:02Z-
dc.date.available2019-12-09T06:51:02Z-
dc.date.issued2018-09-
dc.identifier.citationKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v. 22, no. 5, page. 547-554en_US
dc.identifier.issn1226-4512-
dc.identifier.issn2093-3827-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.4196/kjpp.2018.22.5.547-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/120131-
dc.description.abstractItching is a common clinical symptom of skin disease that significantly affects a patient's quality of life. Transient receptor potential vanilloid 1 (TRPV1) receptors of keratinocytes and peripheral nerve fibers in skin are involved in the regulation of itching as well as pain. In this study, we investigated whether curcumin, which acts on TRPV1 receptors, affects histamine-induced itching in mice, using behavioral tests and electrophysiological approaches. We found that histamine-induced itching was blocked by topical application of curcumin in a concentration-dependent manner. In ex-vivo recordings, histamine-induced discharges of peripheral nerves were reduced by the application of curcumin, indicating that curcumin acts directly on peripheral nerves. Additionally, curcumin blocked the histamine-induced inward current via activation of TRPV1 (curcumin IC50 = 523 nM). However, it did not alter chloroquine-induced itching behavior in mice, which is associated with transient receptor potential ankyrin 1 (TRPA 1). Taken together, our results suggest that histamine-induced itching can be blocked by topical application of curcumin through the inhibitory action of curcumin on TRPV1 receptors in peripheral nerves.en_US
dc.description.sponsorshipThis work was supported by the research fund of Hanyang University (HY-2013-N).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGYen_US
dc.subjectCurcuminen_US
dc.subjectHistamineen_US
dc.subjectItchingen_US
dc.subjectTRPV1en_US
dc.titleAntipruritic effect of curcumin on histamine-induced itching in miceen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume22-
dc.identifier.doi10.4196/kjpp.2018.22.5.547-
dc.relation.page547-554-
dc.relation.journalKOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY-
dc.contributor.googleauthorLee, Han Kyu-
dc.contributor.googleauthorPark, Seok Bum-
dc.contributor.googleauthorChang, Su-youne-
dc.contributor.googleauthorJung, Sung Jun-
dc.relation.code2018004103-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pideurijj-


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