Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이원준 | - |
dc.date.accessioned | 2019-12-09T01:16:12Z | - |
dc.date.available | 2019-12-09T01:16:12Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | PLOS ONE, v. 13, no. 9, Article no. e0204069 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204069 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119984 | - |
dc.description.abstract | PurposeTo investigate the effect of eye movement on the optic nerve head (ONH) using swept-source optical coherence tomography (SS-OCT), and to measure the degree of ONH changes.MethodsWe enrolled 52 healthy subjects, 20 to 40 years of age, and performed a prospective observational study. Both ONH and macula were imaged simultaneously using wide volume scan of the SS-OCT in the primary and different gaze positions. Horizontal eye movements were used to obtain OCT images in abducted and adducted eyeball positions. Multilateral 3-dimensional registration was used to process and analyze the images to measure the degree of ONH changes.ResultsThe mean axial length (AXL) was 25.73 +/- 1.42mm and the mean spherical equivalents was -4.49 +/- 2.94 D (The proportion of high myopia was 39.4%). Significant morphologic changes were observed in the ONH during both abduction and adduction. In abduction, the overall ONH tissues were elevated, and the mean area of elevation was 115,134 +/- 9,424 mu m(2) (p<0.001). In adduction, the mean areas from two perspectives, which were nasal or temporal, and peripapillary tissues or optic nerve cupping were 95,277 +/- 73,846 mu m(2), 34,450 +/- 44,948 mu m(2), -108,652 +/- 91,246 mu m(2), and -30,581 +/- 46,249 mu m(2), respectively. Elevation in abduction (overall, nasal cup segment, and temporal cup segment; R = 0.204, 0.195 and 0.225, p = 0.038, 0.047 and 0.021, respectively) and elevation of nasal peripapillary segments in adduction were positively correlated with AXL (R = 0.346, p<0.001).ConclusionWe found significant morphologic changes in the ONH in both abduction and adduction and these changes were associated with AXL. Considering these morphologic changes as physical properties, it allows a better understanding of the biomechanical characteristics of the ONH. | en_US |
dc.description.sponsorship | This study was supported by grants to Han Woong Lim from the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2016R1C1B2015164). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE | en_US |
dc.subject | COHERENCE TOMOGRAPHY | en_US |
dc.subject | MULTIPLE-SCLEROSIS | en_US |
dc.subject | AXON DIAMETER | en_US |
dc.subject | DUCTION | en_US |
dc.subject | DEFORMATIONS | en_US |
dc.subject | SHEATH | en_US |
dc.subject | LAYER | en_US |
dc.subject | GAZE | en_US |
dc.title | Changes in the optic nerve head induced by horizontal eye movements | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 13 | - |
dc.identifier.doi | 10.1371/journal.pone.0204069 | - |
dc.relation.page | 1-13 | - |
dc.relation.journal | PLOS ONE | - |
dc.contributor.googleauthor | Lee, Won June | - |
dc.contributor.googleauthor | Kim, Yu Jeong | - |
dc.contributor.googleauthor | Kim, Ji Hong | - |
dc.contributor.googleauthor | Hwang, Sunjin | - |
dc.contributor.googleauthor | Shin, Seung Hak | - |
dc.contributor.googleauthor | Lim, Han Woong | - |
dc.relation.code | 2018006288 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | wjoon0208 | - |
dc.identifier.researcherID | Y-8207-2018 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-3506-7139 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.