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Changes in the optic nerve head induced by horizontal eye movements

Title
Changes in the optic nerve head induced by horizontal eye movements
Author
이원준
Keywords
COHERENCE TOMOGRAPHY; MULTIPLE-SCLEROSIS; AXON DIAMETER; DUCTION; DEFORMATIONS; SHEATH; LAYER; GAZE
Issue Date
2018-09
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v. 13, no. 9, Article no. e0204069
Abstract
PurposeTo investigate the effect of eye movement on the optic nerve head (ONH) using swept-source optical coherence tomography (SS-OCT), and to measure the degree of ONH changes.MethodsWe enrolled 52 healthy subjects, 20 to 40 years of age, and performed a prospective observational study. Both ONH and macula were imaged simultaneously using wide volume scan of the SS-OCT in the primary and different gaze positions. Horizontal eye movements were used to obtain OCT images in abducted and adducted eyeball positions. Multilateral 3-dimensional registration was used to process and analyze the images to measure the degree of ONH changes.ResultsThe mean axial length (AXL) was 25.73 +/- 1.42mm and the mean spherical equivalents was -4.49 +/- 2.94 D (The proportion of high myopia was 39.4%). Significant morphologic changes were observed in the ONH during both abduction and adduction. In abduction, the overall ONH tissues were elevated, and the mean area of elevation was 115,134 +/- 9,424 mu m(2) (p<0.001). In adduction, the mean areas from two perspectives, which were nasal or temporal, and peripapillary tissues or optic nerve cupping were 95,277 +/- 73,846 mu m(2), 34,450 +/- 44,948 mu m(2), -108,652 +/- 91,246 mu m(2), and -30,581 +/- 46,249 mu m(2), respectively. Elevation in abduction (overall, nasal cup segment, and temporal cup segment; R = 0.204, 0.195 and 0.225, p = 0.038, 0.047 and 0.021, respectively) and elevation of nasal peripapillary segments in adduction were positively correlated with AXL (R = 0.346, p<0.001).ConclusionWe found significant morphologic changes in the ONH in both abduction and adduction and these changes were associated with AXL. Considering these morphologic changes as physical properties, it allows a better understanding of the biomechanical characteristics of the ONH.
URI
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204069https://repository.hanyang.ac.kr/handle/20.500.11754/119984
ISSN
1932-6203
DOI
10.1371/journal.pone.0204069
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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