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DC FieldValueLanguage
dc.contributor.author최규선-
dc.date.accessioned2019-12-08T20:49:47Z-
dc.date.available2019-12-08T20:49:47Z-
dc.date.issued2018-09-
dc.identifier.citationSCIENTIFIC REPORTS, v. 8, Article no. 14137en_US
dc.identifier.issn2045-2322-
dc.identifier.urihttps://www.nature.com/articles/s41598-018-32543-7-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/119969-
dc.description.abstractDecreased thyroid hormone (TH) has been considered as one of the potential predictors of mortality in sepsis. This study aimed to evaluate the prognostic impact of decreased TH on mortality in septic patients during intensive care unit (ICU) admission. We included studies that assessed thyroid function by measuring the serum thyroid hormone level and in-hospital mortality in adult septic patients. Reviews, case reports, editorials, letters, commentaries, animal studies, duplicate studies, and studies with irrelevant populations and inappropriate controls were excluded. A total of 1,578 patients from eight studies were included. Triiodothyronine levels in non-survivors were relatively lower than that of survivors (6 studies; standardized mean difference [SMD] 2.31; 95% confidence interval (CI), 0.52-4.10; I-2 = 97%; P = 0.01). Thyroxine levels in non-survivors were also lower than that of survivors (5 studies; SMD 2.40; 95% CI, 0.91-3.89). There were no statistically significant differences in thyroid-stimulating hormone levels between non-survivors and survivors. The present meta-analysis suggested that the decreased TH during ICU admission might be associated with the increase in mortality in adult septic patients. Hence, the measurement of TH could provide prognostic information on mortality in adult septic patients.en_US
dc.language.isoen_USen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectNONTHYROIDAL ILLNESS SYNDROMEen_US
dc.subjectCRITICALLY-ILL PATIENTSen_US
dc.subjectHOSPITALIZED-PATIENTSen_US
dc.subjectFUNCTION TESTSen_US
dc.subjectSEPSISen_US
dc.subjectDYSFUNCTIONen_US
dc.subjectASSOCIATIONen_US
dc.subjectMECHANISMSen_US
dc.subjectSEVERITYen_US
dc.subjectSERUMen_US
dc.titleThe Value of Decreased Thyroid Hormone for Predicting Mortality in Adult Septic Patients: A Systematic Review and Meta-Analysisen_US
dc.typeArticleen_US
dc.relation.volume8-
dc.identifier.doi10.1038/s41598-018-32543-7-
dc.relation.page1-9-
dc.relation.journalSCIENTIFIC REPORTS-
dc.contributor.googleauthorKim, Jae Guk-
dc.contributor.googleauthorShin, Hyungoo-
dc.contributor.googleauthorKim, Wonhee-
dc.contributor.googleauthorLim, Tae Ho-
dc.contributor.googleauthorJang, Bohyoung-
dc.contributor.googleauthorCho, Youngsuk-
dc.contributor.googleauthorChoi, Kyu-Sun-
dc.contributor.googleauthorAhn, Chiwon-
dc.contributor.googleauthorLee, Juncheol-
dc.contributor.googleauthorNa, Min Kyun-
dc.relation.code2018003596-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidvertex09-


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