Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 방소영 | - |
dc.date.accessioned | 2019-12-08T20:39:18Z | - |
dc.date.available | 2019-12-08T20:39:18Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | HUMAN MOLECULAR GENETICS, v. 27, no. 22, page. 3901-3910 | en_US |
dc.identifier.issn | 0964-6906 | - |
dc.identifier.issn | 1460-2083 | - |
dc.identifier.uri | https://academic.oup.com/hmg/article-abstract/27/22/3901/5061929?redirectedFrom=fulltext | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119940 | - |
dc.description.abstract | Crohn's disease (CD) and ulcerative colitis (UC) are the major types of chronic inflammatory bowel disease (IBD) characterized by recurring episodes of inflammation of the gastrointestinal tract. Although it is well established that human leukocyte antigen (HLA) is a major risk factor for IBD, it is yet to be determined which HLA alleles or amino acids drive the risks of CD and UC in Asians. To define the roles of HLA for IBD in Asians, we fine-mapped HLA in 12 568 individuals from Korea and Japan (3294 patients with CD, 1522 patients with UC and 7752 controls). We identified that the amino acid position 37 of HLA-DR beta 1 plays a key role in the susceptibility to CD (presence of serine being protective, P = 3.6 x 10(-67), OR = 0.48 [0.45-0.52]). For UC, we confirmed the known association of the haplotype spanning HLA-C*12:02, HLA-B*52:01 and HLA-DRB1*1502 (P = 1.2 x 10(-28), OR = 4.01 [3.14-5.12]). | en_US |
dc.description.sponsorship | PLSI supercomputing resources of the Korea Institute of Science and Technology Information; Korean Health Technology R & D Project grant through the Korea Health Industry Development Institute (A120176 to S.-K.Y.), funded by the Ministry of Health & Welfare; Mid-Career Researcher Program grant through the National Research Foundation of Korea (2017R1A2A1A05001119 to K.S.), funded by the Ministry of Science, Information & Communication Technology, and Future Planning of the Republic of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | OXFORD UNIV PRESS | en_US |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | en_US |
dc.subject | ULCERATIVE-COLITIS | en_US |
dc.subject | HLA ALLELES | en_US |
dc.subject | ASSOCIATION | en_US |
dc.subject | RISK | en_US |
dc.subject | LOCI | en_US |
dc.subject | MHC | en_US |
dc.subject | INTRACTABILITY | en_US |
dc.subject | PROTEINS | en_US |
dc.subject | DQ | en_US |
dc.title | Amino acid position 37 of HLA-DR beta 1 affects susceptibility to Crohn's disease in Asians | en_US |
dc.type | Article | en_US |
dc.relation.no | 22 | - |
dc.relation.volume | 27 | - |
dc.identifier.doi | 10.1093/hmg/ddy285 | - |
dc.relation.page | 3901-3910 | - |
dc.relation.journal | HUMAN MOLECULAR GENETICS | - |
dc.contributor.googleauthor | Han, Buhm | - |
dc.contributor.googleauthor | Akiyama, Masato | - |
dc.contributor.googleauthor | Kim, Kyung-Kon | - |
dc.contributor.googleauthor | Oh, Hyunjung | - |
dc.contributor.googleauthor | Choi, Hyunchul | - |
dc.contributor.googleauthor | Lee, Cue Hyunkyu | - |
dc.contributor.googleauthor | Jung, Seulgi | - |
dc.contributor.googleauthor | Lee, Ho-Su | - |
dc.contributor.googleauthor | Kim, Emma E. | - |
dc.contributor.googleauthor | Bang, So-Young | - |
dc.relation.code | 2018001445 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | sybang | - |
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