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dc.contributor.author이종민-
dc.date.accessioned2019-12-08T20:36:26Z-
dc.date.available2019-12-08T20:36:26Z-
dc.date.issued2018-09-
dc.identifier.citationJOURNAL OF ALZHEIMERS DISEASE, v. 65, no. 4, page. 1237-1246en_US
dc.identifier.issn1387-2877-
dc.identifier.issn1875-8908-
dc.identifier.urihttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad170537-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/119936-
dc.description.abstractBackground/Objective: In this study, we investigated a long-term trajectory of brain aging (from the 20 s to over-80) in cognitively normal (CN) individuals. We further determined whether differences in sex, education years, and apolipoprotein E epsilon 4 status affect age-related cortical thinning.Methods: A total of 2,944 CN individuals who underwent high-resolution (3.0-Tesla) magnetic resonance imaging were included in this study. Cortical thickness was measured using a surface-based method. Multiple linear regression analyses were performed to evaluate age-related cortical thinning and related factors.Results: Compared to those in their 20 s/30 s, participants in their 40 s showed thinning primarily in the medial and lateral frontal and inferior parietal regions, and cortical thinning occurred across most of the cortices with increasing age. Notably, the precuneus, inferior temporal and lateral occipital regions were relatively spared until later in life. Male and lower education years were associated with greater cortical thinning with distinct regional specificity.Conclusion: Our findings provide an important clue to understanding the mechanism of age-related cognitive decline and new strategies for preventing the acceleration of pathological brain aging.en_US
dc.description.sponsorshipThis research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2016M3C7A1913844), by the NRF grant funded by the Korean government (2015R1C1A2A01053281), by the NRF grant funded by the Korea government (2017R1A2B2005081), by the Korea Ministry of Environment as the Environmental Health Action Program (2014001360002), by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (HI17C1915) and by a fund (2018-ER6203-00) by Research of Korea Centers for Disease Control and Prevention.en_US
dc.language.isoen_USen_US
dc.publisherIOS PRESSen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectcognitive disordersen_US
dc.subjectdementiaen_US
dc.subjectmagnetic resonance imagingen_US
dc.titleTrajectories of Physiological Brain Aging and Related Factors in People Aged from 20 to over-80en_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume65-
dc.identifier.doi10.3233/JAD-170537-
dc.relation.page1237-1246-
dc.relation.journalJOURNAL OF ALZHEIMERS DISEASE-
dc.contributor.googleauthorLee, Jin San-
dc.contributor.googleauthorKim, Seonwoo-
dc.contributor.googleauthorYoo, Heejin-
dc.contributor.googleauthorPark, Seongbeom-
dc.contributor.googleauthorJang, Young Kyoung-
dc.contributor.googleauthorKim, Hee Jin-
dc.contributor.googleauthorKim, Ko Woon-
dc.contributor.googleauthorKim, Yeshin-
dc.contributor.googleauthorJang, Hyemin-
dc.contributor.googleauthorLee, Jong-Min-
dc.relation.code2018008431-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING-
dc.identifier.pidljm-
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COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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