Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이형중 | - |
dc.date.accessioned | 2019-12-08T20:13:04Z | - |
dc.date.available | 2019-12-08T20:13:04Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.citation | BRAIN RESEARCH BULLETIN, v. 142, page. 122-128 | en_US |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.issn | 1873-2747 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S036192301730566X?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119859 | - |
dc.description.abstract | Objective: Hydrogen inhalation has been found to be neuroprotective and anti-oxidative in several brain injury models. Building on these studies, we investigated potential neuroprotective effects of hydrogen inhalation in a rat model of intracerebral hemorrhage (ICH), focusing on apoptosis and inflammation.Methods: Forty-five 8-week-old male Sprague-Dawley rats were randomly divided into three groups (n = 15 per each group): a sham group, ICH group, and ICH + hydrogen group. Induction of ICH was performed via injection of 0.23 U of bacterial collagenase type IV into the left striatum. Hydrogen was administered via spontaneous inhalation. Mortality and neurologic deficits were investigated at 6, 24, and 48 h after ICH. To investigate the antioxidative activity of hydrogen gas, the expression of malondialdehyde was measured. Real-time polymerase chain reaction analyses of TNF-a, IL-lb, BDNF, and caspase-3 expression were used to detect anti-inflammatory and anti-apoptotic effects. Neuroprotective effect was evaluated by immunohistochemical and TUNEL staining.Result At 6, 24 and 48 h post-intracerebral hemorrhage, animals showed brain edema and neurologic deficits, accompanied by up-regulation of TNF-a, IL-b, BDNF, and caspase-3, which is indicative of neuroinflammation, neuroprotection, and apoptosis. Hydrogen treatment significantly reduced the level of oxidative stress, neuroinflammation, neuronal damage, and apoptosis-related genes. This was accompanied by increased neurogenesis and expression of growth factor-related genes at < 24 h, but not 48 h, after ICH.Conclusion: H-2 gas administration exerted a neuroprotective effect against early brain injury after ICH through anti-inflammatory, neuroprotective, anti-apoptotic, and antioxidative activity. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number: 2015R1D1A1A02062530). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | Hydrogen | en_US |
dc.subject | Neuroprotection | en_US |
dc.subject | Intracerebral hemorrhage | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Rat | en_US |
dc.subject | Apoptosis | en_US |
dc.title | Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model | en_US |
dc.type | Article | en_US |
dc.relation.volume | 142 | - |
dc.identifier.doi | 10.1016/j.brainresbull.2018.07.006 | - |
dc.relation.page | 122-128 | - |
dc.relation.journal | BRAIN RESEARCH BULLETIN | - |
dc.contributor.googleauthor | Choi, Kyu-Sun | - |
dc.contributor.googleauthor | Kim, Han-Jun | - |
dc.contributor.googleauthor | Do, Sun Hee | - |
dc.contributor.googleauthor | Hwang, Se Jin | - |
dc.contributor.googleauthor | Yi, Hyeong-Joong | - |
dc.relation.code | 2018001300 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hjyi8499 | - |
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