Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-12-08T19:53:33Z | - |
dc.date.available | 2019-12-08T19:53:33Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.citation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v. 77, no. 6, page. 522-532 | en_US |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.issn | 1435-1250 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00393-017-0328-y | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119781 | - |
dc.description.abstract | The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA).We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients.The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272-0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164-0.480, p = 6.4 x 10(-5)). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033-0.258, p = 0.012).Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | Anti-P. gingivalis antibody | en_US |
dc.subject | Anti-citrullinated protein antibodies | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.title | Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis A meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 77 | - |
dc.identifier.doi | 10.1007/s00393-017-0328-y | - |
dc.relation.page | 522-532 | - |
dc.relation.journal | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.contributor.googleauthor | Bae, S. -C. | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.relation.code | 2018001384 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
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