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Cyanobacteria-specific algicidal mechanism of bioinspired naphthoquinone derivative, NQ 2-0

Title
Cyanobacteria-specific algicidal mechanism of bioinspired naphthoquinone derivative, NQ 2-0
Author
한명수
Keywords
PROGRAMMED CELL-DEATH; OXIDATIVE STRESS; CHLOROPHYLL FLUORESCENCE; MICROCYSTIS-AERUGINOSA; PHOTOSYNTHESIS; PLANKTON; BINDING
Issue Date
2018-08
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 8, Article no. 11595
Abstract
To mitigate cyanobacterial blooms, the naphthoquinone derivative, NQ 2-0, which has selective algicidal activity against cyanobacteria, has been developed. However, due to a lack of information on its algicidal mechanisms, there are significant gaps in our understanding of how this substance is capable of selectively killing cyanobacteria. Here, we investigated the selective algicidal mechanisms of NQ 2-0 using target (Microcystis aeruginosa) and non-target (Cyclotella sp. and Selenastrum capricornutum) species. NQ 2-0 showed selective algicidal activity against only M. aeruginosa, and this activity was strongly light-dependent. This NQ compound has selectively reduced the oxygen evolution rate and photosystem II (PSII) efficiency of M. aeruginosa throughout blocking electron transfer from the photosynthetic electron transport system, and significantly (p <= 0.05) increased levels of reactive oxygen species (ROS), resulting in membrane damage through lipid peroxidation. In ultrastructural observations, thylakoid membranes were disintegrated within 12 h after NQ 2-0 treatment, and cytoplasmic vacuolation and disintegrated cellular membrane were observed at 24 h. These findings suggest that increased ROS levels following NQ 2-0 treatment may induce cell death. Interestingly, compared to non-target eukaryotic cells, M. aeruginosa showed relatively late antioxidant response to reduce the increased ROS level, this may enhance algicidal activity against this cyanobacterium.
URI
https://www.nature.com/articles/s41598-018-29976-5https://repository.hanyang.ac.kr/handle/20.500.11754/119759
ISSN
2045-2322
DOI
10.1038/s41598-018-29976-5
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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