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dc.contributor.author한상웅-
dc.date.accessioned2019-12-08T17:27:10Z-
dc.date.available2019-12-08T17:27:10Z-
dc.date.issued2018-07-
dc.identifier.citationKOREAN JOURNAL OF INTERNAL MEDICINE, v. 33, no. 4, page. 763-773en_US
dc.identifier.issn1226-3303-
dc.identifier.issn2005-6648-
dc.identifier.urihttp://kjim.org/journal/view.php?doi=10.3904/kjim.2016.097-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/119493-
dc.description.abstractBackground/Aims: This study was designed to investigate the roles of aristolochic acid I (AA-I) and hypokalemia in acute aristolochic acid nephropathy (AAN).Methods: After an adaptation period (1 week), a total of 40 C57BL/6 mice (male, 8 weeks old) were divided into four groups: I (control group), II (low potassium [K] diet), III (normal K diet with administration ofAA-I [10 mg/kg weight]), and IV (low K diet with AA-I). After collecting 24 hours of urine at 2 weeks, the mice were sacrificed, and their blood and kidneys were obtained to perform immunochemical staining and/or Western blot analysis.Results: Proteinuria, glycosuria, and increased fractional excretion of sodium and K were prominent in groups III and IV (p < 0.05). Diffuse swelling and poor staining of collecting duct epithelial cells were evident in the medullas of group II. Typical lesions of toxic acute tubular injury were prominent in the cortices of groups III and IV. A-Smooth muscle actin (a-SMA) was higher in the cortices of the mice in groups III and IV versus group II (p < 0.05), and higher in the medullas of group IV than groups I and III (p < 0.05). E-cadherin was higher in the cortices of groups III and IV compared to group I (p < 0.05). The F4/80 value was higher in the cortices and medullas of groups II, III, and IV compared to group I (p < 0.05), particularly in the case of group II.Conclusions: AA-I can induce acquired Fanconi syndrome in the acute stage of AAN. Macrophages appear to play a key role in the pathogenesis of AAN and hypokalemic nephropathy. It remains uncertain whether hypokalemia plays any role in AAN and hypokalemia.en_US
dc.description.sponsorshipThis study was supported by a grant from Korean Society of Nephrology (GAMBRO 2006).en_US
dc.language.isoen_USen_US
dc.publisherKOREAN ASSOC INTERNAL MEDICINEen_US
dc.subjectAristolochic acid Ien_US
dc.subjectBalkan nephropathyen_US
dc.subjectHypokalemiaen_US
dc.subjectMacrophagesen_US
dc.titleEffects of aristolochic acid I and/or hypokalemia on tubular damage in C57BL/6 rat with aristolochic acid nephropathyen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume33-
dc.identifier.doi10.3904/kjim.2016.097-
dc.relation.page763-773-
dc.relation.journalKOREAN JOURNAL OF INTERNAL MEDICINE-
dc.contributor.googleauthorYi, Joo-Hark-
dc.contributor.googleauthorHan, Sang-Woong-
dc.contributor.googleauthorKim, Wan-Young-
dc.contributor.googleauthorKim, Jin-
dc.contributor.googleauthorPark, Moon-Hyang-
dc.relation.code2018006805-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidcardion-
dc.identifier.researcherIDQ-1458-2015-
dc.identifier.orcidhttp://orcid.org/0000-0003-3658-7248-


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