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Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Fas(lPr) Mice

Title
Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Fas(lPr) Mice
Author
배상철
Keywords
IMMUNOSUPPRESSIVE DRUGS; STROMAL CELLS; TRANSPLANTATION; GLUCOCORTICOIDS; ERYTHEMATOSUS; MECHANISMS; RAPAMYCIN; THERAPY
Issue Date
2018-07
Publisher
HINDAWI LTD
Citation
STEM CELLS INTERNATIONAL, Article no. 4273107
Abstract
The combination of immunosuppressants and mesenchymal stem cells (MSCs) is a promising therapeutic strategy for systemic lupus erythematosus, since this approach reduces doses of immunosuppressants while maintaining the same therapeutic outcome. However, it is unavoidable for MSCs to be exposed to immunosuppressants. Here, we examined the combination effect of prednisone (PD) or mycophenolate mofetil (MMF) and MSCs. We showed that PD or MMF in combination with MSCs showed better therapeutic effect than single therapy in lupus-prone MRL.Fas(lPr) mice, as assessed by using the following readouts: prolongation of survival, decrease in anti-dsDNA and total IgG levels in serum, decrease in cytokine gene expression in spleen cells, and decrease in inflammatory cell infiltration into the kidney. In vitro, immunosuppressants and MSCs inhibited T cell proliferation in a synergistic manner. However, immunosuppressants did not affect MSC viability and functions such as TGF-beta 1 and PGE(2) production, migration, and immunosuppressive capacity. In summary, our study demonstrates that a combination of immunosuppressants and MSCs is a good strategy to reduce the side effects of PD and MMF without the loss of therapeutic outcome.
URI
https://www.hindawi.com/journals/sci/2018/4273107/https://repository.hanyang.ac.kr/handle/20.500.11754/119475
ISSN
1687-966X; 1687-9678
DOI
10.1155/2018/4273107
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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