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dc.contributor.author최규선-
dc.date.accessioned2019-12-08T14:47:57Z-
dc.date.available2019-12-08T14:47:57Z-
dc.date.issued2018-07-
dc.identifier.citationPLOS ONE, v. 13, no. 7, Article no. e0200379en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200379-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/119412-
dc.description.abstractIntroductionThis study aimed to determine the diagnostic accuracy of adding copeptin to cardiac troponin (cTn) on admission to the emergency department (ED) for non-ST elevation myocardial infarction (NSTEMI) compared to cTn alone.Materials and methodsA literature search of MEDLINE, EMBASE, and the Cochrane Library was performed (search date: April 13, 2018). Primary studies were included if they accurately reported on patients with symptoms suggestive of acute myocardial infarction and measured both cTn alone and cTn with copeptin upon admission to the ED. The patients with evidence of ST elevation myocardial infarction were excluded. To assess the risk of bias for the included studies, the QUADAS-2 tool was used.ResultsThe study participants included a total of 7,998 patients from 14 observational studies. The addition of copeptin to cTn significantly improved the sensitivity (0.81 [0.74 to 0.87] vs. 0.92 [0.89 to 0.95], respectively, p < 0.001) and negative predictive value (0.96 [0.95 to 0.98] vs. 0.98 [0.96 to 0.99], respectively, p < 0.001) at the expense of lower specificity (0.88 [0.80 to 0.97] vs. 0.57 [0.49 to 0.65], respectively, p < 0.001) compared to cTn alone. Furthermore, adding copeptin to cTn showed significantly lower diagnostic accuracy for NSTEMI compared to cTn alone (0.91[0.90 to 0.92] vs. 0.85 [0.83 to 0.86], respectively, p < 0.001).ConclusionsAdding copeptin to cTn improved the sensitivity and negative predictive value for the diagnosis of NSTEMI compared to cTn alone. Thus, adding copeptin to cTn might help to screen NSTEMI early upon admission to the ED.en_US
dc.language.isoen_USen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.subjectACUTE CORONARY SYNDROMEen_US
dc.subjectHIGH-SENSITIVITY TROPONINen_US
dc.subjectEARLY RULE-OUTen_US
dc.subjectACUTE CHEST-PAINen_US
dc.subjectEMERGENCY-DEPARTMENTen_US
dc.subjectINCREMENTAL VALUEen_US
dc.subjectRAPID RULEen_US
dc.subjectUNIVERSAL DEFINITIONen_US
dc.subjectASSAYSen_US
dc.subjectBIOMARKERSen_US
dc.titleDiagnostic accuracy of adding copeptin to cardiac troponin for non-ST-elevation myocardial infarction: A systematic review and meta-analysisen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume13-
dc.identifier.doi10.1371/journal.pone.0200379-
dc.relation.page1-14-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorShin, Hyungoo-
dc.contributor.googleauthorJang, Bo-Hyoung-
dc.contributor.googleauthorLim, Tae Ho-
dc.contributor.googleauthorLee, Juncheol-
dc.contributor.googleauthorKim, Wonhee-
dc.contributor.googleauthorCho, Youngsuk-
dc.contributor.googleauthorAhn, Chiwon-
dc.contributor.googleauthorChoi, Kyu-Sun-
dc.relation.code2018006288-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidvertex09-


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