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dc.contributor.author정진혁-
dc.date.accessioned2019-12-08T14:00:43Z-
dc.date.available2019-12-08T14:00:43Z-
dc.date.issued2018-07-
dc.identifier.citationALLERGY AND ASTHMA PROCEEDINGS, v. 39, no. 4, page. E30-E37en_US
dc.identifier.issn1088-5412-
dc.identifier.issn1539-6304-
dc.identifier.urihttps://www.ingentaconnect.com/content/ocean/aap/2018/00000039/00000004/art00001;jsessionid=bvm4tvk1ik0r.x-ic-live-02-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/119358-
dc.description.abstractBackground: Local allergic rhinitis (LAR) is rhinitis with a localized nasal allergic response in. the absence of systemic allergy. This study aimed to evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) and nonallergic rhinitis (NAR) by using cytokines from polypous tissues.Methods: We recruited 43 patients with AR (n = 15; mean age, 17.4 years), LAR (n = 12; mean age, 15.9 years), and NAR (n = 16; mean age, 15.6 years) who underwent polypectomy. Atopic status was defined as presenting a sufficiently high total immunoglobulin E (IgE) serum concentration and skin-prick test or serum allergen test. Immunoassays were performed by using polyp tissue homogenates to quantify the levels of regulated on activation of normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF) alpha, interleukin (IL) 5, and sera to assess total IgE and eosinophil cationic protein.Results: RANTES levels were higher in patients with LAR than in patients with AR and NAR. There was a significant correlation in the concentration of RANTES between polyp tissue homogenates and serum (R-2 = 0.51, p < 0.05). The levels of IL-5, TNF alpha, and interferon gamma also demonstrated positive correlations between polyp tissue homogenates and serum; however, they were not significantly different.Conclusion: Results of our study indicated that RANTES ma yplay an important role and contribute to allergic reaction in LAR, and RANTES may be related to the pathogenesis of LAR.en_US
dc.description.sponsorshipThis study was supported by the fund from 2015 Hanyang University Clinical Study Project.en_US
dc.language.isoen_USen_US
dc.publisherOCEAN SIDE PUBLICATIONS INCen_US
dc.subjectCHRONIC RHINOSINUSITISen_US
dc.subjectIDIOPATHIC RHINITISen_US
dc.subjectIMMUNOGLOBULIN-Een_US
dc.subjectTNF-ALPHAen_US
dc.subjectMUCOSAen_US
dc.subjectIGEen_US
dc.subjectEXPRESSIONen_US
dc.subjectRANTESen_US
dc.subjectCELLSen_US
dc.subjectMICEen_US
dc.titleDifferences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitisen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume39-
dc.identifier.doi10.2500/aap.2018.39.4135-
dc.relation.page30-37-
dc.relation.journalALLERGY AND ASTHMA PROCEEDINGS-
dc.contributor.googleauthorChoi, Young-Jin-
dc.contributor.googleauthorKang, Ha-Na-
dc.contributor.googleauthorKim, Joo-Hwa-
dc.contributor.googleauthorOh, Jae-Won-
dc.contributor.googleauthorJeong, Jin Hyeok-
dc.relation.code2018010951-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pident-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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