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Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis

Title
Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis
Author
정진혁
Keywords
CHRONIC RHINOSINUSITIS; IDIOPATHIC RHINITIS; IMMUNOGLOBULIN-E; TNF-ALPHA; MUCOSA; IGE; EXPRESSION; RANTES; CELLS; MICE
Issue Date
2018-07
Publisher
OCEAN SIDE PUBLICATIONS INC
Citation
ALLERGY AND ASTHMA PROCEEDINGS, v. 39, no. 4, page. E30-E37
Abstract
Background: Local allergic rhinitis (LAR) is rhinitis with a localized nasal allergic response in. the absence of systemic allergy. This study aimed to evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) and nonallergic rhinitis (NAR) by using cytokines from polypous tissues.Methods: We recruited 43 patients with AR (n = 15; mean age, 17.4 years), LAR (n = 12; mean age, 15.9 years), and NAR (n = 16; mean age, 15.6 years) who underwent polypectomy. Atopic status was defined as presenting a sufficiently high total immunoglobulin E (IgE) serum concentration and skin-prick test or serum allergen test. Immunoassays were performed by using polyp tissue homogenates to quantify the levels of regulated on activation of normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF) alpha, interleukin (IL) 5, and sera to assess total IgE and eosinophil cationic protein.Results: RANTES levels were higher in patients with LAR than in patients with AR and NAR. There was a significant correlation in the concentration of RANTES between polyp tissue homogenates and serum (R-2 = 0.51, p < 0.05). The levels of IL-5, TNF alpha, and interferon gamma also demonstrated positive correlations between polyp tissue homogenates and serum; however, they were not significantly different.Conclusion: Results of our study indicated that RANTES ma yplay an important role and contribute to allergic reaction in LAR, and RANTES may be related to the pathogenesis of LAR.
URI
https://www.ingentaconnect.com/content/ocean/aap/2018/00000039/00000004/art00001;jsessionid=bvm4tvk1ik0r.x-ic-live-02https://repository.hanyang.ac.kr/handle/20.500.11754/119358
ISSN
1088-5412; 1539-6304
DOI
10.2500/aap.2018.39.4135
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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