Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Wook Hong | - |
dc.date.accessioned | 2019-12-08T13:38:48Z | - |
dc.date.available | 2019-12-08T13:38:48Z | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, v. 46, no. sup. 3, page. S318-S327 | en_US |
dc.identifier.issn | 2169-1401 | - |
dc.identifier.issn | 2169-141X | - |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1492420 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119339 | - |
dc.description.abstract | Hypoxia, which results from an inadequate supply of oxygen, is a major cause of concern in cancer therapy as it is associated with a reduction in the effectiveness of chemotherapy and radiotherapy in cancer treatment. Overexpression and stabilization of hypoxia-inducible factor 1 alpha (HIF-1 alpha) protein in tumours, due to hypoxia, results in poor prognosis and increased patient mortality. To increase oxygen tension in hypoxic areas, micro- and nanobubbles have been investigated by various researchers. In the present research, lipid-shelled oxygen nanobubbles (ONBs) were synthesized through a sonication method to reverse hypoxic conditions created in a custom-made hypoxic chamber. Release of oxygen gas from ONBs in deoxygenated water was evaluated by measuring dissolved oxygen. Hypoxic conditions were evaluated by performing in vitro experiments on MDA-MB231 breast cancer cells through the expression of HIF-1 alpha and the fluorescence of image-iT (TM) hypoxia reagent. The results indicated the degradation of HIF-1 alpha after the introduction of ONBs. We propose that ONBs are successful in reversing hypoxia, downregulating HIF-1 alpha, and improving cellular conditions, leading to further medical applications. | en_US |
dc.description.sponsorship | This study was supported by the Nano-Material Technology Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (No. 2017M3A7B8061942). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | TAYLOR & FRANCIS LTD | en_US |
dc.subject | oxygen nanobubbles | en_US |
dc.subject | HIF-1 alpha | en_US |
dc.subject | MDA-MB231 | en_US |
dc.title | Engineering oxygen nanobubbles for the effective reversal of hypoxia | en_US |
dc.type | Article | en_US |
dc.relation.no | sup3 | - |
dc.relation.volume | 46 | - |
dc.identifier.doi | 10.1080/21691401.2018.1492420 | - |
dc.relation.page | 318-327 | - |
dc.relation.journal | Artificial Cells, Nanomedicine and Biotechnology | - |
dc.contributor.googleauthor | Khan, Muhammad Saad | - |
dc.contributor.googleauthor | Hwang, Jangsun | - |
dc.contributor.googleauthor | Seo, Youngmin | - |
dc.contributor.googleauthor | Shin, Kyusoon | - |
dc.contributor.googleauthor | Lee, Kyungwoo | - |
dc.contributor.googleauthor | Park, Chanhwi | - |
dc.contributor.googleauthor | Choi, Yonghyun | - |
dc.contributor.googleauthor | Hong, Jong Wook | - |
dc.contributor.googleauthor | Choi, Jonghoon | - |
dc.relation.code | 2018022302 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | jwh | - |
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