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dc.contributor.author장기석-
dc.date.accessioned2019-12-08T11:56:22Z-
dc.date.available2019-12-08T11:56:22Z-
dc.date.issued2018-06-
dc.identifier.citationMEDICINE, v. 97, no. 25, Article no. e10996en_US
dc.identifier.issn0025-7974-
dc.identifier.issn1536-5964-
dc.identifier.urihttps://insights.ovid.com/crossref?an=00005792-201806220-00014-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/119199-
dc.description.abstractLung cancer is the most common cause of cancer-associated death worldwide. Postoperative relapse and subsequent metastasis result in a high mortality rate, even in early stage lung cancer. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level and are frequently dysregulated in various cancers. The aim of this study was to identify recurrence-associated miRNAs in early stage lung cancer. To screen for differentially expressed miRNAs related to postoperative recurrence, miRNA microarray data derived from stage I lung adenocarcinoma formalin-fixed paraffin-embedded (FFPE) tissue samples (n=6) and publically available the Cancer Genome Atlas (TCGA) data were analyzed. An independent sample (n=29) was used to validate candidate miRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). In miRNA expression profiling, we identified 60 significantly dysregulated miRNAs in the relapsed group. Additionally, 20 dysregulated miRNAs were found using TCGA data set. Three miRNAs (let-7g-5p, miR-143-3p, and miR-374a-5p) were associated with postoperative recurrence in both microarray and TCGA data sets. All 3 candidate miRNAs were validated in the independent cohort of stage I adenocarcinoma by qRT-PCR. We discovered 3 recurrence-associated miRNAs of stage I lung adenocarcinoma samples using FFPE tissue, which showed possible clinical utility as biomarkers predicting recurrence after curative surgery. Further investigation of the functional properties of these miRNAs is needed.en_US
dc.description.sponsorshipThis work was funded by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2015R1C1A1A01056091).en_US
dc.language.isoen_USen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.subjectlung canceren_US
dc.subjectmicroRNAen_US
dc.subjectrecurrenceen_US
dc.subjectstageen_US
dc.titleIdentification of recurrence-associated microRNAs in stage I lung adenocarcinomaen_US
dc.typeArticleen_US
dc.relation.no25-
dc.relation.volume97-
dc.identifier.doi10.1097/MD.0000000000010996-
dc.relation.page1-6-
dc.relation.journalMEDICINE-
dc.contributor.googleauthorSim, Jongmin-
dc.contributor.googleauthorKim, Yeseul-
dc.contributor.googleauthorKim, Hyunsung-
dc.contributor.googleauthorShin, Su-Jin-
dc.contributor.googleauthorKim, Dong-Hoon-
dc.contributor.googleauthorPaik, Seung Sam-
dc.contributor.googleauthorJang, Kiseok-
dc.relation.code2018002227-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidmedartisan-


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