Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장기석 | - |
dc.date.accessioned | 2019-12-08T11:56:22Z | - |
dc.date.available | 2019-12-08T11:56:22Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | MEDICINE, v. 97, no. 25, Article no. e10996 | en_US |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://insights.ovid.com/crossref?an=00005792-201806220-00014 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119199 | - |
dc.description.abstract | Lung cancer is the most common cause of cancer-associated death worldwide. Postoperative relapse and subsequent metastasis result in a high mortality rate, even in early stage lung cancer. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level and are frequently dysregulated in various cancers. The aim of this study was to identify recurrence-associated miRNAs in early stage lung cancer. To screen for differentially expressed miRNAs related to postoperative recurrence, miRNA microarray data derived from stage I lung adenocarcinoma formalin-fixed paraffin-embedded (FFPE) tissue samples (n=6) and publically available the Cancer Genome Atlas (TCGA) data were analyzed. An independent sample (n=29) was used to validate candidate miRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). In miRNA expression profiling, we identified 60 significantly dysregulated miRNAs in the relapsed group. Additionally, 20 dysregulated miRNAs were found using TCGA data set. Three miRNAs (let-7g-5p, miR-143-3p, and miR-374a-5p) were associated with postoperative recurrence in both microarray and TCGA data sets. All 3 candidate miRNAs were validated in the independent cohort of stage I adenocarcinoma by qRT-PCR. We discovered 3 recurrence-associated miRNAs of stage I lung adenocarcinoma samples using FFPE tissue, which showed possible clinical utility as biomarkers predicting recurrence after curative surgery. Further investigation of the functional properties of these miRNAs is needed. | en_US |
dc.description.sponsorship | This work was funded by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (no. 2015R1C1A1A01056091). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | lung cancer | en_US |
dc.subject | microRNA | en_US |
dc.subject | recurrence | en_US |
dc.subject | stage | en_US |
dc.title | Identification of recurrence-associated microRNAs in stage I lung adenocarcinoma | en_US |
dc.type | Article | en_US |
dc.relation.no | 25 | - |
dc.relation.volume | 97 | - |
dc.identifier.doi | 10.1097/MD.0000000000010996 | - |
dc.relation.page | 1-6 | - |
dc.relation.journal | MEDICINE | - |
dc.contributor.googleauthor | Sim, Jongmin | - |
dc.contributor.googleauthor | Kim, Yeseul | - |
dc.contributor.googleauthor | Kim, Hyunsung | - |
dc.contributor.googleauthor | Shin, Su-Jin | - |
dc.contributor.googleauthor | Kim, Dong-Hoon | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.relation.code | 2018002227 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | medartisan | - |
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