Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영복 | - |
dc.date.accessioned | 2019-12-08T09:21:01Z | - |
dc.date.available | 2019-12-08T09:21:01Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | CHEMPHYSCHEM, v. 19, no. 17, page. 2143-2147 | en_US |
dc.identifier.issn | 1439-4235 | - |
dc.identifier.issn | 1439-7641 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201800461 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/119070 | - |
dc.description.abstract | Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for Si-29 magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their Si-29 MR signals; the particles demonstrated long Si-29 spin-lattice relaxation (T-1) times (approximate to 25mins), which suggests potential applicability for medical imaging. Furthermore, Si-29 hyperpolarization levels were sufficient to allow Si-29 MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes invivo. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B03932107), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (HI17C0830). This 29Si DNP and MR imaging portion of the research was funded by NCI R25T CA057730, CPRIT grant RP150701, MDACC Institutional Research Grants, MDACC Institutional Startup, MDACC Odyssey Postdoctoral Fellowship, NCI R25T CA057730, DoD PC131680, NCI U54 CA151668, P50 CA083639, NCI R21 CA185536, GCC/Keck center CCBTP postdoctoral fellowship (CPRIT RP170593), John S. Dunn Foundation Collaborative Research Award administered by the Gulf Coast Consortia, and NCI Cancer Center Support Grant CA016672. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | porous silicon nanoparticles | en_US |
dc.subject | DNP | en_US |
dc.subject | molecular magnetic resonance imaging | en_US |
dc.subject | theragnostic material | en_US |
dc.subject | Si-29 hyperpolarization | en_US |
dc.title | Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for Si-29 Magnetic Resonance Imaging | en_US |
dc.type | Article | en_US |
dc.relation.no | 17 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1002/cphc.201800461 | - |
dc.relation.page | 2143-2147 | - |
dc.relation.journal | CHEMPHYSCHEM | - |
dc.contributor.googleauthor | Seo, Hyeonglim | - |
dc.contributor.googleauthor | Choi, Ikjang | - |
dc.contributor.googleauthor | Whiting, Nicholas | - |
dc.contributor.googleauthor | Hu, Jingzhe | - |
dc.contributor.googleauthor | Luu, Quy Son | - |
dc.contributor.googleauthor | Pudakalakatti, Shivanand | - |
dc.contributor.googleauthor | McCowan, Caitlin | - |
dc.contributor.googleauthor | Kim, Yaewon | - |
dc.contributor.googleauthor | Zacharias, Niki | - |
dc.contributor.googleauthor | Lee, Youngbok | - |
dc.relation.code | 2018003391 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | yblee | - |
dc.identifier.orcid | http://orcid.org/0000-0002-8392-0827 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.