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Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for Si-29 Magnetic Resonance Imaging

Title
Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for Si-29 Magnetic Resonance Imaging
Author
이영복
Keywords
porous silicon nanoparticles; DNP; molecular magnetic resonance imaging; theragnostic material; Si-29 hyperpolarization
Issue Date
2018-06
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMPHYSCHEM, v. 19, no. 17, page. 2143-2147
Abstract
Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for Si-29 magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their Si-29 MR signals; the particles demonstrated long Si-29 spin-lattice relaxation (T-1) times (approximate to 25mins), which suggests potential applicability for medical imaging. Furthermore, Si-29 hyperpolarization levels were sufficient to allow Si-29 MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes invivo.
URI
https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201800461https://repository.hanyang.ac.kr/handle/20.500.11754/119070
ISSN
1439-4235; 1439-7641
DOI
10.1002/cphc.201800461
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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