Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이강홍 | - |
dc.date.accessioned | 2019-12-08T07:21:23Z | - |
dc.date.available | 2019-12-08T07:21:23Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.citation | GASTROENTEROLOGY RESEARCH AND PRACTICE, Article no. 7968149 | en_US |
dc.identifier.issn | 1687-6121 | - |
dc.identifier.issn | 1687-630X | - |
dc.identifier.uri | https://www.hindawi.com/journals/grp/2018/7968149/ | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118994 | - |
dc.description.abstract | Introduction. Cyclooxygenase-2 (COX-2) expression is elevated in colorectal cancer (CRC). However, data about the relation between COX-2 expression and the impact on the biologic behavior of recurrent disease are inconclusive as yet. The aim of this study is to investigate the relationship between the status of COX-2 expression in the primary CRC and the characteristics of recurrence after curative resection of stage I to III CRC. Materials and Methods. Ninety-eight patients with recurrence in 376 CRC patients, who underwent curative surgery between January 1991 and August 2001, were retrospectively assessed. Immunohistochemical staining, performed for the presence of COX-2 on tissue microarrays, was analyzed. Results. Forty-six patients showed elevated COX-2 expression, and 52 patients did not. The mean time to recurrence was significantly longer in the positive group than in the negative group (34.1 months +/- 30.0 versus 21.9 months 17.4; P = 0.019). Positive COX-2 expression was correlated with late recurrence (>3 years after surgery) [43.5% versus 13.5%; P = 0.001]. In multivariate analysis, COX-2 expression was an independent factor associated with late recurrence (OR 4.656; 95% CI, 1.696 to 12.779; P = 0.003). Recurrence pattern and postrecurrence survival were not different between the two groups. Conclusions. Elevated COX-2 expression in itself is not a prognostic factor, but COX-2 expression in tumor tissue may be an independent predictive marker of late recurrence for patients with stage Ito III CRC. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | HINDAWI LTD | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | UP-REGULATION | en_US |
dc.subject | CARCINOMA | en_US |
dc.subject | SURVIVIN | en_US |
dc.subject | COX-2 | en_US |
dc.subject | ADENOCARCINOMAS | en_US |
dc.subject | PREVENTION | en_US |
dc.subject | TARGET | en_US |
dc.title | Cyclooxygenase-2 Expression Is a Predictive Marker for Late Recurrence in Colorectal Cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1155/2018/7968149 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | GASTROENTEROLOGY RESEARCH AND PRACTICE | - |
dc.contributor.googleauthor | Kim, Sung Hoo | - |
dc.contributor.googleauthor | Ahn, Byung Kyu | - |
dc.contributor.googleauthor | Paik, Seung Sam | - |
dc.contributor.googleauthor | Lee, Kang Hong | - |
dc.relation.code | 2018010660 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | leekh | - |
dc.identifier.researcherID | K-6201-2017 | - |
dc.identifier.orcid | https://orcid.org/0000-0003-3857-9137 | - |
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