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2D transition metal dichalcogenides with glucan multivalency for antibody-free pathogen recognition

Title
2D transition metal dichalcogenides with glucan multivalency for antibody-free pathogen recognition
Author
이상욱
Keywords
INITIO MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; ESCHERICHIA-COLI; MOS2; WS2; PHOTOLUMINESCENCE; EXFOLIATION; NANOSHEETS; WATER; BINDING
Issue Date
2018-06
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v. 9, Article no. 2549
Abstract
The ability to control the dimensions and properties of nanomaterials is fundamental to the creation of new functions and improvement of their performances in the applications of interest. Herein, we report a strategy based on glucan multivalent interactions for the simultaneous exfoliation and functionalization of two-dimensional transition metal dichal-cogenides (TMDs) in an aqueous solution. The multivalent hydrogen bonding of dextran with bulk TMDs (WS2, WSe2, and MoSe2) in liquid exfoliation effectively produces TMD monolayers with binding multivalency for pathogenic bacteria. Density functional theory simulation reveals that the multivalent hydrogen bonding between dextran and TMD monolayers is very strong and thermodynamically favored (Delta E-b = -0.52 eV). The resulting dextran/TMD hybrids (dex-TMDs) exhibit a stronger affinity (K-d = 11 nM) to Escherichia coli O157:H7 (E. coli) than E. coli-specific antibodies and aptamers. The dex-TMDs can effectively detect a single copy of E. coli based on their Raman signal.
URI
https://www.nature.com/articles/s41467-018-04997-whttps://repository.hanyang.ac.kr/handle/20.500.11754/118963
ISSN
2041-1723
DOI
10.1038/s41467-018-04997-w
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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