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dc.contributor.author한명훈-
dc.date.accessioned2019-12-08T02:49:24Z-
dc.date.available2019-12-08T02:49:24Z-
dc.date.issued2018-05-
dc.identifier.citationPLOS ONE, v. 13, no. 5, Article no. e0197336en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197336-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/118678-
dc.description.abstractBackground and purposeOsteoporosis is one of the most common chronic metabolic diseases, but detection and treatment rates are low. The aim of the current study was to evaluate the correlation between frontal skull Hounsfield unit (HU) values from brain computed tomography (CT) scans and T-scores of the lumbar spine and femoral neck from dual-energy X-ray absorptiometry (DXA) scans.MethodsPatients with < 1 year between brain CT and DXA scans were included in the study. The average frontal skull HU value used for analysis was defined as the average of four HU values of the frontal bone. A receiver operating characteristic curve was generated, and area under the curve (AUC) was used to determine the HU values of the frontal skull for predicting osteoporosis. The frontal skull HU value with the highest sensitivity and specificity was considered the optimal cutoff value.ResultsIn total, 899 patients who underwent both brain CT and DXA scans at a single institution were enrolled. Average skull HU values differed significantly among patients in different bone mineral density categories (p < 0.001). There was a positive correlation between skull HU value and T-score (beta = 105.06, p < 0.001, R-2 = 0.343). The mean HU value in subjects with osteoporosis was 515, and the optimal cutoff value for the prediction of osteoporosis was 610 HU (AUC = 0.775, 95% CI 0.744-0.806, p < 0.001).ConclusionsClinical brain CT scans can assist in the detection of osteoporosis, and patients with an HU value < 610 as determined via brain CT may be considered for further evaluation for possible osteoporosis.en_US
dc.language.isoen_USen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.subjectBONE-MINERAL DENSITYen_US
dc.subjectMANAGEMENTen_US
dc.subjectSCANSen_US
dc.subjectFRACTURESen_US
dc.subjectTOOLen_US
dc.titleOpportunistic osteoporosis screening via the measurement of frontal skull Hounsfield units derived from brain computed tomography imagesen_US
dc.typeArticleen_US
dc.relation.no5-
dc.relation.volume13-
dc.identifier.doi10.1371/journal.pone.0197336-
dc.relation.page0-0-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorNa, Min Kyun-
dc.contributor.googleauthorWon, Yu Deok-
dc.contributor.googleauthorKim, Choong Hyun-
dc.contributor.googleauthorKim, Jae Min-
dc.contributor.googleauthorCheong, Jin Hwan-
dc.contributor.googleauthorRyu, Je Il-
dc.contributor.googleauthorHan, Myung-Hoon-
dc.relation.code2018006288-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidgksmh80-


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