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dc.contributor.author이영복-
dc.date.accessioned2019-12-07T23:50:37Z-
dc.date.available2019-12-07T23:50:37Z-
dc.date.issued2018-05-
dc.identifier.citationBIOMACROMOLECULES, v. 19, no. 7, page. 2682-2690en_US
dc.identifier.issn1525-7797-
dc.identifier.issn1526-4602-
dc.identifier.urihttps://pubs.acs.org/doi/10.1021/acs.biomac.8b00292-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/118547-
dc.description.abstractWe herein propose a polymeric nanovehicle system that has the ability to remarkably improve cellular uptake and transdermal delivery. Cell-penetrating peptide-patchy deformable polymeric nano vehicles were fabricated by tailored coassembly of amphiphilic poly-(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL), mannosylerythritol lipid (MEL), and YGRKKRRQRRR-cysteamine (TAT)-linked MEL. Using X-ray diffraction, differential scanning calorimetry, and nuclear magnetic resonance analyses, we revealed that the incorporation of MEL having an asymmetric alkyl chain configuration was responsible for the deformable phase property of the vehicles. We also discovered that the nanovehicles were mutually attracted, exhibiting a gel-like fluid characteristic due to the dipole dipole interaction between the hydroxyl group of MEL and the methoxy group of PEO-b-PCL. Coassembly of TAT-linked MEL with the deformable nanovehicles significantly enhanced cellular uptake due to macropinocytosis and caveolae-/lipid raft-mediated endocytosis. Furthermore, the in vivo skin penetration test revealed that our TAT-patchy deformable nanovehicles remarkably improved transdermal delivery efficiency.en_US
dc.description.sponsorshipThis research was supported by Coway Co. Ltd. and by National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIP) (2011-0030049, 2016R1A2B2016148, and 2018M3A9G2057170).en_US
dc.language.isoen_USen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectOF-THE-ARTen_US
dc.subjectDRUG-DELIVERYen_US
dc.subjectTOPICAL DELIVERYen_US
dc.subjectLIPID NANOPARTICLESen_US
dc.subjectTAT PEPTIDEen_US
dc.subjectIN-VIVOen_US
dc.subjectNMR-SPECTROSCOPYen_US
dc.subjectSKIN PENETRATIONen_US
dc.subjectBIOAVAILABILITYen_US
dc.subjectLIPOSOMESen_US
dc.titleCell-Penetrating Peptide-Patchy Deformable Polymeric Nanovehicles with Enhanced Cellular Uptake and Transdermal Deliveryen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume19-
dc.identifier.doi10.1021/acs.biomac.8b00292-
dc.relation.page2682-2690-
dc.relation.journalBIOMACROMOLECULES-
dc.contributor.googleauthorPark, Daehwan-
dc.contributor.googleauthorLee, Jin Yong-
dc.contributor.googleauthorCho, Heui Kyoung-
dc.contributor.googleauthorHong, Woo Jin-
dc.contributor.googleauthorKim, Jisun-
dc.contributor.googleauthorSeo, Hyemyung-
dc.contributor.googleauthorChoi, Ikjang-
dc.contributor.googleauthorLee, Younbok-
dc.contributor.googleauthorKim, Juheon-
dc.contributor.googleauthorMin, Sun-Joon-
dc.relation.code2018001476-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidyblee-
dc.identifier.orcidhttp://orcid.org/0000-0002-8392-0827-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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