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dc.contributor.author최정혜-
dc.date.accessioned2019-12-07T20:26:55Z-
dc.date.available2019-12-07T20:26:55Z-
dc.date.issued2018-04-
dc.identifier.citationCANCER RESEARCH AND TREATMENT, v. 50, no. 2, page. 590-598en_US
dc.identifier.issn1598-2998-
dc.identifier.issn2005-9256-
dc.identifier.urihttps://www.e-crt.org/journal/view.php?doi=10.4143/crt.2017.172-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/118423-
dc.description.abstractPurposeThe treatment strategy for elderly patients older than 80 years with diffuse large B-cell lymphoma (DLBCL) has not been established because of poor treatment tolerability and lack of data.Materials and MethodsThis multicenter retrospective study was conducted to investigate clinical characteristics, treatment patterns and outcomes of patients older than 80 years who were diagnosed with DLBCL at 19 institutions in Korea between 2005 and 2016.ResultsA total of 194 patients were identified (median age, 83.3 years). Of these, 114 patients had an age-adjusted International Prognostic Index (aaIPI) score of 2-3 and 48 had a Charlson index score of 4 or more. R-CHOP was given in 124 cases, R-CVP in 13 cases, other chemotherapy in 17 cases, radiation alone in nine cases, and surgery alone in two cases. Twenty-nine patients did not undergo any treatment. The median number of chemotherapy cycles was three. Only 37 patients completed the planned treatment cycles. The overall response rate from 105 evaluable patients was 90.5% (complete response, 41.9%). Twenty-nine patients died due to treatment-related toxicities (TRT). Thirteen patients died due to TRT after the first cycle. Median overall survival was 14.0 months. The main causes of death were disease progression (30.8%) and TRT (27.1%). In multivariate analysis, overall survival was affected by aaIPI, hypoalbuminemia, elevated creatinine, and treatment.ConclusionAge itself should not be a contraindication to treatment. However, since elderly patients show higher rates of TRT due to infection, careful monitoring and dose modification of chemotherapeutic agents is needed.en_US
dc.description.sponsorshipThis research was supported in part by the Korean Cancer Study Group.en_US
dc.language.isoen_USen_US
dc.publisherKOREAN CANCER ASSOCIATIONen_US
dc.subjectDiffuse large B-cell lymphomaen_US
dc.subjectAgeden_US
dc.subjectInfectionen_US
dc.titleMulticenter Retrospective Analysis of Clinical Characteristics, Treatment Patterns, and Outcomes in Very Elderly Patients with Diffuse Large B-Cell Lymphoma: The Korean Cancer Study Group LY16-01en_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume50-
dc.identifier.doi10.4143/crt.2017.172-
dc.relation.page590-598-
dc.relation.journalCANCER RESEARCH AND TREATMENT-
dc.contributor.googleauthorChoi, Jung Hye-
dc.contributor.googleauthorKim, Tae Min-
dc.contributor.googleauthorKim, Hyo Jung-
dc.contributor.googleauthorKoh, Sung Ae-
dc.contributor.googleauthorMun, Yeung-Chul-
dc.contributor.googleauthorKang, Hye Jin-
dc.contributor.googleauthorJung, Yun Hwa-
dc.contributor.googleauthorShim, Hyeok-
dc.contributor.googleauthorChong, So Young-
dc.contributor.googleauthorSun, Der-Sheng-
dc.relation.code2018004348-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjhcmd-


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