Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis
- Title
- Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis
- Author
- 배상철
- Keywords
- PTPN22; Autoimmune diseases; Meta-analysis
- Issue Date
- 2018-04
- Publisher
- C M B ASSOC
- Citation
- CELLULAR AND MOLECULAR BIOLOGY, v. 64, no. 5, page. 46-51
- Abstract
- This study explored whether the functional protein tyrosine phosphatase nonreceptor 22 (PTPN22) G788A(R263Q) polymorphism is associated with susceptibility to autoimmune diseases. A meta-analysis was conducted using 23 comparative studies with a total of 16,719 patients and 17,783 controls. The meta analysis showed an association between the A allele of the PTPN22 C1788A polymorphism and decreased risk of autoimmune diseases in all subjects (p < 0.001). Analysis after stratification by ethnicity indicated that the PTPN22 788A allele was significantly associated with autoimmune diseases in Europeans (p < 0.001) hut not in Latin Americans. Meta-analysis by autoimmune disease type showed a significant negative association between the PTPN22 788A allele and systemic lupus erythematous (SLE) (p = 001), rheumatoid arthritis (RA) (p = 0.008), ulcerative colitis (UC) (p = 0.016), but not Crohn's disease (CD). A single study for each showed no association between the PTPN22 788A allele and systemic sclerosis, giant cell arteritis, Henoch-schonlein purpura, uveitis, and Grave's disease. This meta-analysis demonstrates that the PTPN22 0788A polymorphism confers protection against SLE, RA, and UC, supporting evidence of association of the PTPN22 gene with a subgroup of autoimmune diseases.
- URI
- https://www.cellmolbiol.org/index.php/CMB/article/view/1774https://repository.hanyang.ac.kr/handle/20.500.11754/118396
- ISSN
- 0145-5680; 1165-158X
- DOI
- 10.14715/cmb/2018.64.5.7
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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