17 0

Correlation between circulating VEGF levels and disease activity in rheumatoid arthritis: a meta-analysis

Title
Correlation between circulating VEGF levels and disease activity in rheumatoid arthritis: a meta-analysis
Author
배상철
Keywords
VEGF; Level; Polymorphism; Rheumatoid arthritis
Issue Date
2018-04
Publisher
SPRINGER HEIDELBERG
Citation
ZEITSCHRIFT FUR RHEUMATOLOGIE, v. 77, no. 3, page. 240-248
Abstract
Objective. To systematically review evidence regarding the relationship between circulating vascular endothelial growth factor (VEGF) levels and rheumatoid arthritis (RA), the correlation between serum VEGF levels and RA activity, and the association between VEGF polymorphisms and RA susceptibility. Methods. We conducted a meta-analysis of the serum/plasma VEGF levels in patients with RA and controls, the correlation coefficients between the circulating VEGF levels and disease activity in patients with RA, and the association between VEGF -2578 A/C, -634 C/G, + 936 T/C, and -1154 A/G polymorphisms and the risk for RA. Results. In total, 13 studies including 2508 patients with RA and 2489 controls were included. Meta-analysis revealed that VEGF level was significantly higher in the RA than in the control group (standard mean difference [SMD] = 1.480, 95% confidence interval [CI] = 0.71-2.241, p = 1.4 x 10-4). Stratification by adjustment for age and gender revealed significantly higher VEGF levels for the adjustment and non-adjustment groups in the RA group (SMD = 1.360, 95% CI = 0.445-2.276, p = 0.004; SMD = 1.557, 95% CI = 0.252-2.861, p = 0.019, respectively). Meta-analysis of correlation coefficients showed a significantly positive correlation between circulating VEGF levels and disease activity in RA, and between circulating VEGF and C-reactive protein levels. However, no association was found between RA and the VEGF -2578 A/C, -634 C/G, + 936 T/C, and -1154 A/G polymorphisms. Conclusion. Our meta-analysis revealed significantly higher circulating VEGF levels in patients with RA and a positive correlation between VEGF levels and disease activity in RA, but no association between the VEGF -2578 A/C, -634 C/G,+ 936 T/C, and -1154 A/G polymorphisms and the development of RA.
URI
https://link.springer.com/article/10.1007%2Fs00393-016-0229-5https://repository.hanyang.ac.kr/handle/20.500.11754/118395
ISSN
0340-1855; 1435-1250
DOI
10.1007/s00393-016-0229-5
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE