Copper(I)-Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Azidoformates and Aryl Terminal Alkynes
- Title
- Copper(I)-Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Azidoformates and Aryl Terminal Alkynes
- Author
- 이학준
- Keywords
- ONE-POT SYNTHESIS; CLICK CHEMISTRY; ROOM-TEMPERATURE; SULFONYL AZIDES; ANTI-3-ARYL-2,3-DIBROMOPROPANOIC ACIDS; MEDICINAL CHEMISTRY; ORGANIC AZIDES; SODIUM-AZIDE; SOLID-PHASE; CYCLOADDITION
- Issue Date
- 2018-04
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF ORGANIC CHEMISTRY, v. 83, no. 8, page. 4805-4811
- Abstract
- The copper(I)-catalyzed azide-alkyne cycloaddition reaction has been extensively studied and widely applied in organic synthesis. However, the formation of 1,2,3-triazoles with electron-deficient azide has been a challenging problem. In this report, we have demonstrated the formation of regioselective 1,4-disubstituted 1,2,3-triazoles from various types of aryl terminal alkynes and azidoformates, which are electron-deficient azides, using a commercialized [Cu-(CH3CN)(4)]PF6 copper(I) catalyst under mild conditions.
- URI
- https://pubs.acs.org/doi/10.1021/acs.joc.8b00022https://repository.hanyang.ac.kr/handle/20.500.11754/118215
- ISSN
- 0022-3263
- DOI
- 10.1021/acs.joc.8b00022
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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