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Surfactant-free solubilization and systemic delivery of anti-cancer drug using low molecular weight methylcellulose

Title
Surfactant-free solubilization and systemic delivery of anti-cancer drug using low molecular weight methylcellulose
Author
김용희
Keywords
Surfactant-free solubilization; Systemic drug delivery; Low molecular weight methylcellulose; Anti-cancer drug
Issue Date
2018-04
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CONTROLLED RELEASE, v. 276, page. 42-49
Abstract
Docetaxel, an advanced taxoid, has been widely used as an anti-mitotic agent, but further augmentation of its properties is still required, including improvement in low aqueous solubility. Herein, we report the development of bio-eliminable low molecular weight methylcellulose-based surfactant-free injectable formulation for the delivery of docetaxel. Crude methylcellulose, a hydrophobically modified cellulose derivative, was hydrolyzed by an enzymatic degradation method to obtain low molecular weight methylcellulose (LMwMC). Docetaxel was successfully loaded in micelles with small particle sizes high drug loading and sustained release profile. The in vivo anti-cancer effects of intravenously injected nanoparticle systems in B16F10 melanoma xenograft mice were evaluated and demonstrated a significantly enhanced therapeutic effect with the docetaxel-LMwMC micellar aggregates compared to a commercially available docetaxel, Taxotere (R). Surfactant-free solubilization of docetaxel could be a promising delivery method for effective insoluble drug delivery for anti-tumor efficacy.
URI
https://www.sciencedirect.com/science/article/pii/S0168365918300968?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/118175
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2018.02.028
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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