Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김용석 | - |
dc.date.accessioned | 2019-12-06T08:00:30Z | - |
dc.date.available | 2019-12-06T08:00:30Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | 대한소화기학회지, v. 71, no. 3, page. 132-142 | en_US |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.issn | 2233-6869 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.4166/kjg.2018.71.3.132 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/118011 | - |
dc.description.abstract | Background/Aims: Several lines of evidence from epidemiologic and laboratory studies have shown that the consumption of Artemisia or green tea extracts (MPGT) is inversely associated with the risk of alcohol-induced damage and other chronic diseases. Supported by previous studies showing that the combined extract of Artemisia and green tea, MPGT, exerted significantly either antioxidative or anti-inflammatory actions against Helicobacter pylori-associated gastric diseases, it was hypothesized that MPGT can offer protection against alcoholic gastritis.Methods: Ethanol was administered to induce gastric damage in Wistar rats, which had been pretreated with various doses of MPGT, to measure the rescuing action of a MPGT pretreatment against ethanol-induced gastric damage. In addition, the molecular mechanisms for the preventive effects were examined.Results: The MPGT pretreatment (100, 300, and 500 mg/kg) alleviated the ethanol-induced gastric damage, which was evidenced by the significant decrease in calcium-dependent phospholipase A2, MAPKs, and NF-B levels compared to ethanol alone. Furthermore, the MPGT pretreatment preserved 15-prostaglandin dehydrogenase, whereas cyclooxygenase-2 was decreased significantly. All of these biochemical changes led to the significant alleviation of alcohol-associated gastric mucosal damage. Ethanol significantly increased the TUNEL positivity in the stomach, but MPGT decreased the apoptotic index significantly, which was associated with significantly lower pathological scores of ethanol-induced mucosal ulcerations. The significant protective changes observed alcoholic gastritis with MPGT were related to the increased expression of cytoprotective genes, such as heat-shock protein (HSP)27, HSP60, and PDGF.Conclusions: The efficient anti-inflammatory, anti-apoptotic, and regenerative actions of MPGT make it a potential nutrient phytoceutical to rescue the stomach from alcoholic gastritis. | en_US |
dc.description.sponsorship | Financial support: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministryof Education (2014R1A1A2058732 to JM Park), by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET)through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (116015-03-1-CG000), andalso by Japanese Society for Promotion of Science. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | 대한소화기학회 | en_US |
dc.subject | Ethanol | en_US |
dc.subject | Gastric damages | en_US |
dc.subject | Artemisia extracts | en_US |
dc.subject | Green tea extracts | en_US |
dc.subject | HSP27 | en_US |
dc.title | Combined Extracts of Artemisia and Green Tea, Mitigated Alcoholic Gastritis Via Enhanced Heat-shock Protein 27 | en_US |
dc.title.alternative | Artemisia와 Green Tea 추출 복합물의 Heat-shock Protein 27 발현 증가를 통한 알코올성 위염 억제 효과 | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 71 | - |
dc.identifier.doi | 10.4166/kjg.2018.71.3.132 | - |
dc.relation.page | 132-142 | - |
dc.relation.journal | The Korean journal of gastroenterology | - |
dc.contributor.googleauthor | Kim, Yong Seok | - |
dc.contributor.googleauthor | Jeong, Migyeong | - |
dc.contributor.googleauthor | Han, Young Min | - |
dc.contributor.googleauthor | Park, Jong-Min | - |
dc.contributor.googleauthor | Kwon, Sang Oh | - |
dc.contributor.googleauthor | Hong, Seong Pyo | - |
dc.contributor.googleauthor | Hahm, Ki Baik | - |
dc.contributor.googleauthor | 김용석 | - |
dc.contributor.googleauthor | 정미경 | - |
dc.contributor.googleauthor | 한영민 | - |
dc.contributor.googleauthor | 박종민 | - |
dc.contributor.googleauthor | 권상오 | - |
dc.contributor.googleauthor | 홍성표 | - |
dc.contributor.googleauthor | 함기백 | - |
dc.relation.code | 2012211627 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | yongsk | - |
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