Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현 | - |
dc.date.accessioned | 2019-12-06T07:32:46Z | - |
dc.date.available | 2019-12-06T07:32:46Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | RESPIRATORY RESEARCH, v. 19, Article no. UNSP 36 | en_US |
dc.identifier.issn | 1465-993X | - |
dc.identifier.issn | 1465-9921 | - |
dc.identifier.uri | https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-018-0737-8 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117991 | - |
dc.description.abstract | Background: The recognition of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) as a distinct phenotype of COPD or asthma has increased. Although ACO has worse clinical features than non-ACO COPD, limited information is available on long-term outcomes of lung function decline for ACO and non-ACO COPD.Methods: COPD patients with at least 3 years of follow-up were selected from the Korean Obstructive Lung Disease cohort. ACO was defined based on 3 major criteria: 1) airflow limitation in individuals 40 years of age and older, 2) >= 10 pack-years of smoking history, and 3) a history of asthma or bronchodilator response of > 400 mL in forced expiratory volume in 1 s (FEV1) at baseline; and at least 1 minor criterion: 1) history of atopy or allergic rhinitis, 2) two separated bronchodilator responses of >= 12% and 200 mL in FEV1, or 3) peripheral blood eosinophils >= 300 cells/mu L. Lung function decline was compared using a linear mixed effects model for longitudinal data with random intercept and random slope.Results: Among 239 patients, 47 were diagnosed with ACO (19.7%). During the follow-up period, change in smoking status, use of inhaled corticosteroids (ICS) and long-acting beta 2-agonists or ICS and at least 2 exacerbations per year were similar between patients with non-ACO COPD and ACO. Over a median follow-up duration of 5.8 years, patients with non-ACO COPD experienced a faster annual decline in pre-bronchodilator FEV1 than patients with ACO (-29.3 ml/year vs. -13.9 ml/year, P = 0.042), which was persistent after adjustment for confounders affecting lung function decline.Conclusion: Patients with ACO showed favorable longitudinal changes in lung function compared to COPD patients over a median follow-up of 5.8 years. | en_US |
dc.description.sponsorship | The KOLD Study was supported by a grant from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020 and A102065). This study was supported by Samsung Medical Center Foundation for Medical Research (SMX1151371). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BMC | en_US |
dc.subject | Asthma | en_US |
dc.subject | Chronic obstructive pulmonary disease | en_US |
dc.subject | Lung function | en_US |
dc.title | Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort | en_US |
dc.type | Article | en_US |
dc.relation.no | 36 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1186/s12931-018-0737-8 | - |
dc.relation.page | 1-7 | - |
dc.relation.journal | RESPIRATORY RESEARCH | - |
dc.contributor.googleauthor | Park, Hye Yun | - |
dc.contributor.googleauthor | Lee, Suh-Young | - |
dc.contributor.googleauthor | Kang, Danbee | - |
dc.contributor.googleauthor | Cho, Juhee | - |
dc.contributor.googleauthor | Lee, Hyun | - |
dc.contributor.googleauthor | Lim, Seong Yong | - |
dc.contributor.googleauthor | Yoon, Ho Il | - |
dc.contributor.googleauthor | Ra, Seung Won | - |
dc.contributor.googleauthor | Kim, Ki Uk | - |
dc.contributor.googleauthor | Oh, Yeon-Mok | - |
dc.contributor.googleauthor | Sin, Don D. | - |
dc.contributor.googleauthor | Lee, Sang-Do | - |
dc.contributor.googleauthor | Park, Yong Bum | - |
dc.relation.code | 2018011477 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | namuhanayeyo | - |
dc.identifier.researcherID | G-1336-2018 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-1269-0913 | - |
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