Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 양철수 | - |
dc.date.accessioned | 2019-12-06T01:22:41Z | - |
dc.date.available | 2019-12-06T01:22:41Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.citation | EXPERIMENTAL AND MOLECULAR MEDICINE, v. 50, Article no. e464 | en_US |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.issn | 2092-6413 | - |
dc.identifier.uri | https://www.nature.com/articles/emm2017308 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117784 | - |
dc.description.abstract | The intracellular parasite Toxoplasma gondii has unique dense granule antigens (GRAs) that are crucial for host infection. Emerging evidence suggests that GRA8 of T. gondii is a promising serodiagnostic marker in toxoplasmosis. However, little is known about the intracellular regulatory mechanisms involved in GRA8-induced host responses. We found that GRA8 interacts with host proteins involved in mitochondria activation and might be useful as a therapeutic strategy for sepsis. Here, we show that protein kinase-C alpha (PKC alpha)-mediated phosphorylation of T. gondii GRA8 (Thr220) is required for mitochondrial trafficking and regulates the interaction of C terminal of GRA8 with nucleotide binding domain of ATP5A1. Furthermore, GRA8 interacts with SIRT3 in mitochondria, facilitating ATP5A1 deacetylation (K506 and K531), adenosine triphosphate production and subsequent anti-septic activity in vivo. Taken together, these results demonstrate a new anti-sepsis therapeutic strategy using T. gondii GRA8-induced mitochondrial metabolic resuscitation. This strategy represents an urgently needed paradigm shift for therapeutic intervention. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP), the Ministry of Science, ICT & Future Planning (NRF-2011-0030049 and 2016R1D1A1A02937312) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI16C1653 and HI17C0888). Finally, we thank all members of Yang's lab for their discussions. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | PLACEBO-CONTROLLED TRIAL | en_US |
dc.subject | SEPTIC SHOCK | en_US |
dc.subject | SIRT3 IMPLICATIONS | en_US |
dc.subject | DOUBLE-BLIND | en_US |
dc.subject | IDENTIFICATION | en_US |
dc.subject | RESVERATROL | en_US |
dc.subject | DYSFUNCTION | en_US |
dc.subject | INFECTION | en_US |
dc.subject | MELATONIN | en_US |
dc.subject | THIAMINE | en_US |
dc.title | Toxoplasma gondii GRA8 induces ATP5A1-SIRT3-mediated mitochondrial metabolic resuscitation: a potential therapy for sepsis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 50 | - |
dc.identifier.doi | 10.1038/emm.2017.308 | - |
dc.relation.page | 1-11 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.contributor.googleauthor | Kim, Ye-Ram | - |
dc.contributor.googleauthor | Kim, Jae-Sung | - |
dc.contributor.googleauthor | Yun, Jin-Seung | - |
dc.contributor.googleauthor | Kim, Sojin | - |
dc.contributor.googleauthor | Kim, Sun Young | - |
dc.contributor.googleauthor | Jang, Kiseok | - |
dc.contributor.googleauthor | Yang, Chul-Su | - |
dc.relation.code | 2018002394 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | chulsuyang | - |
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