Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황정욱 | - |
dc.date.accessioned | 2019-12-05T16:41:50Z | - |
dc.date.available | 2019-12-05T16:41:50Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | CELL DEATH AND DIFFERENTIATION, v. 25, no. 2, page. 432-443 | en_US |
dc.identifier.issn | 1350-9047 | - |
dc.identifier.issn | 1476-5403 | - |
dc.identifier.uri | https://www.nature.com/articles/cdd2017182 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117655 | - |
dc.description.abstract | Staufen1 (STAU1) and Lin28B are RNA-binding proteins that are involved in neuronal differentiation as a function of post-transcriptional regulation. STAU1 triggers post-transcriptional regulation, including mRNA export, mRNA relocation, translation and mRNA decay. Lin28B also has multiple functions in miRNA biogenesis and the regulation of translation. Here, we examined the connection between STAU1 and Lin28B and found that Lin28B regulates the abundance of STAU1 mRNA via miRNA maturation. Decreases in the expression of both STAU1 and Lin28B were observed during neuronal differentiation. Depletion of STAU1 or Lin28B inhibited neuronal differentiation, and overexpression of STAU1 or Lin28B enhanced neuronal differentiation. Interestingly, the stability of STAU1 mRNA was modulated by miR-142-3p, whose maturation was regulated by Lin28B. Thus, miR-142-3p expression increased as Lin28B expression decreased during differentiation, leading to the reduction of STAU1 expression. The transcriptome from Staufen-mediated mRNA decay (SMD) targets during differentiation was analyzed, confirming that STAU1 was a key factor in neuronal differentiation. In support of this finding, regulation of STAU1 expression in mouse neural precursor cells had the same effects on neuronal differentiation as it did in human neuroblastoma cells. These results revealed the collaboration of two RNA-binding proteins, STAU1 and Lin28B, as a regulatory mechanism in neuronal differentiation. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea, which is funded by the Ministry of Education, Science and Technology and (2015R1D1A1A01058878 to JH), by the framework of an international cooperation program managed by the NRF of Korea (NRF-2016K2A9A1A01951898 to JH) and by grant from the Medical Research Center (2017R1A5A2015395 to JH), funded by the NRF of Korea of the Ministry of Science and ICT, Republic of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | MESSENGER-RNA DECAY | en_US |
dc.subject | STEM-CELLS | en_US |
dc.subject | SECONDARY STRUCTURES | en_US |
dc.subject | BINDING PROTEIN | en_US |
dc.subject | MICRORNA | en_US |
dc.subject | METABOLISM | en_US |
dc.subject | NEUROGENESIS | en_US |
dc.subject | TRANSLATION | en_US |
dc.subject | SPECIFICITY | en_US |
dc.subject | GRANULES | en_US |
dc.title | Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 25 | - |
dc.identifier.doi | 10.1038/cdd.2017.182 | - |
dc.relation.page | 432-443 | - |
dc.relation.journal | CELL DEATH AND DIFFERENTIATION | - |
dc.contributor.googleauthor | Oh, Younseo | - |
dc.contributor.googleauthor | Park, Jungyun | - |
dc.contributor.googleauthor | Kim, Jin-Il | - |
dc.contributor.googleauthor | Chang, Mi-Yoon | - |
dc.contributor.googleauthor | Lee, Sang-Hun | - |
dc.contributor.googleauthor | Cho, Youl-Hee | - |
dc.contributor.googleauthor | Hwang, Jungwook | - |
dc.relation.code | 2018001047 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | jwhwang | - |
dc.identifier.researcherID | P-1614-2015 | - |
dc.identifier.orcid | http://orcid.org/0000-0002-2290-1649 | - |
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