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dc.contributor.author배상철-
dc.date.accessioned2019-12-05T14:59:52Z-
dc.date.available2019-12-05T14:59:52Z-
dc.date.issued2018-02-
dc.identifier.citationSEMINARS IN ARTHRITIS AND RHEUMATISM, v. 47, no. 4, page. 501-506en_US
dc.identifier.issn0049-0172-
dc.identifier.issn1532-866X-
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0049017217301658?via%3Dihub-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/117586-
dc.description.abstractObjectives: To estimate the incidence of cardiovascular disease (CVD) in Asian patients with rheumatoid arthritis (RA) and to evaluate the impact of anti-rheumatic treatment on the development of CVD.Methods: A retrospective cohort of Asian patients with RA was established to identify the incidence rate (IR) of CVD in RA patients. The cohort was generated using the Korean National Healthcare claims database, which contained claims from Jan 2009 to Dec 2013. A total of 137,512 RA patients were identified; individuals with a history of CVD for 6 months or more before the index date were excluded. Nested case-control samples were drawn from the full study population with a case:control ratio of 1:4 (n = 7102 cases; n = 27,018 controls without CVD). A conditional multivariate regression model was used to evaluate the impact of anti-rheumatic treatment on the development of CVD in RA patients after matching for age, sex, RA index date, comorbidities, and drug use (e.g., antiplatelet agents and cholesterol-lowering agents).Results: The IR for development of overall CVD in RA patients was 182.1 (95% CI: 178.4-185.9) per 10,000 person-years. In models adjusted for other CVD risk factors, disease-modifying anti-rheumatic drugs (DMARDs) (OR = 0.79) were protective against CVD, and biologic DMARDs were not significantly associated with CVD risk (OR = 0.85). Corticosteroids (OR = 1.26) and NSAIDs (nonselective NSAIDs: OR = 1.32, Cox-2 inhibitors: OR = 131) were risk factors for CVD in RA patients.Conclusions: The use of DMARDs is protective against CVD, while corticosteroids and NSAIDs increased the risk of CVD in RA patients.en_US
dc.description.sponsorshipThis research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant no. HC15C3388).en_US
dc.language.isoen_USen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectDMARDsen_US
dc.subjectNSAIDsen_US
dc.subjectCorticosteroidsen_US
dc.titleImpact of anti-rheumatic treatment on cardiovascular risk in Asian patients with rheumatoid arthritisen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume47-
dc.identifier.doi10.1016/j.semarthrit.2017.08.002-
dc.relation.page501-506-
dc.relation.journalSEMINARS IN ARTHRITIS AND RHEUMATISM-
dc.contributor.googleauthorCho, Soo-Kyung-
dc.contributor.googleauthorKim, Dam-
dc.contributor.googleauthorWon, Soyoung-
dc.contributor.googleauthorLee, Jiyoung-
dc.contributor.googleauthorPark, ByeongJu-
dc.contributor.googleauthorJang, Eun Jin-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.contributor.googleauthorSung, Yoon-Kyoung-
dc.relation.code2018002333-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
dc.identifier.orcidhttp://orcid.org/0000-0003-4658-1093-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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