Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도현 | - |
dc.date.accessioned | 2019-12-05T13:14:53Z | - |
dc.date.available | 2019-12-05T13:14:53Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v. 9, Article no. 503 | en_US |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://www.nature.com/articles/s41467-017-02731-6 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117539 | - |
dc.description.abstract | Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators. Deletion of Chi3l1 in T cells in mice show reduced melanoma lung metastasis with increased IFN gamma and TNF alpha-producing T cells in the lung. Furthermore, silencing of Chi3l1 expression in the lung using peptide-siRNA complex (dNP2-siChi3l1) efficiently inhibit lung metastasis with enhanced Th1 and CTL responses. Collectively, this study demonstrates Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity. | en_US |
dc.description.sponsorship | This research was supported by the Basic Science Research Program (NRF-2013R1A1A2A10060048) and the Bio and Medical Technology Development Program (NRF-2017M3A9C8027972) of the NRF funded by the Korean government. This work was also in part supported by grant PO1 HL114501, and R01 HL115813 from National Institute of Health (NIH), USA. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | 3-LIKE 1 | en_US |
dc.subject | INTERFERON-GAMMA | en_US |
dc.subject | NUCLEAR-LOCALIZATION | en_US |
dc.subject | TUMOR ANGIOGENESIS | en_US |
dc.subject | COLORECTAL-CANCER | en_US |
dc.subject | TISSUE RESPONSES | en_US |
dc.subject | BREAST-CANCER | en_US |
dc.subject | MYELOID CELLS | en_US |
dc.subject | CATHEPSIN-E | en_US |
dc.subject | INFLAMMATION | en_US |
dc.title | Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1038/s41467-017-02731-6 | - |
dc.relation.page | 0-0 | - |
dc.relation.journal | NATURE COMMUNICATIONS | - |
dc.contributor.googleauthor | Kim, Do-Hyun | - |
dc.contributor.googleauthor | Park, Hong-Jai | - |
dc.contributor.googleauthor | Lim, Sangho | - |
dc.contributor.googleauthor | Koo, Ja-Hyun | - |
dc.contributor.googleauthor | Lee, Hong-Gyun | - |
dc.contributor.googleauthor | Choi, Jin Ouk | - |
dc.contributor.googleauthor | Oh, Ji Hoon | - |
dc.contributor.googleauthor | Ha, Sang-Jun | - |
dc.contributor.googleauthor | Kang, Min-Jong | - |
dc.contributor.googleauthor | Lee, Chang-Min | - |
dc.relation.code | 2018003595 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | THE RESEARCH INSTITUTE FOR NATURAL SCIENCES | - |
dc.identifier.pid | dhkim86 | - |
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