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Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

Title
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Author
김도현
Keywords
3-LIKE 1; INTERFERON-GAMMA; NUCLEAR-LOCALIZATION; TUMOR ANGIOGENESIS; COLORECTAL-CANCER; TISSUE RESPONSES; BREAST-CANCER; MYELOID CELLS; CATHEPSIN-E; INFLAMMATION
Issue Date
2018-02
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v. 9, Article no. 503
Abstract
Chitinase-3-like-1 (Chi3l1) is known to play a significant role in the pathogenesis of Type 2 inflammation and cancer. However, the function of Chi3l1 in T cell and its clinical implications are largely unknown. Here we show that Chi3l1 expression was increased in activated T cells, especially in Th2 cells. In addition, Chi3l1-deficient T cells are hyper-responsive to TcR stimulation and are prone to differentiating into Th1 cells. Chi3l1-deficient Th1 cells show increased expression of anti-tumor immunity genes and decreased Th1 negative regulators. Deletion of Chi3l1 in T cells in mice show reduced melanoma lung metastasis with increased IFN gamma and TNF alpha-producing T cells in the lung. Furthermore, silencing of Chi3l1 expression in the lung using peptide-siRNA complex (dNP2-siChi3l1) efficiently inhibit lung metastasis with enhanced Th1 and CTL responses. Collectively, this study demonstrates Chi3l1 is a regulator of Th1 and CTL which could be a therapeutic target to enhance anti-tumor immunity.
URI
https://www.nature.com/articles/s41467-017-02731-6https://repository.hanyang.ac.kr/handle/20.500.11754/117539
ISSN
2041-1723
DOI
10.1038/s41467-017-02731-6
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
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