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dc.contributor.author김철영-
dc.date.accessioned2019-12-05T02:09:32Z-
dc.date.available2019-12-05T02:09:32Z-
dc.date.issued2019-07-
dc.identifier.citationNUTRIENTS, v. 11, No. 7, Article no. 1522en_US
dc.identifier.issn2072-6643-
dc.identifier.urihttps://www.mdpi.com/2072-6643/11/7/1522/htm-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/117401-
dc.description.abstractAllomyrina dichotoma larva is a nutritional-worthy future food resource and it contributes to multiple pharmacological functions. However, its antidiabetic effect and molecular mechanisms are not yet fully understood. Therefore, we investigated the hypolipidemic effect of A. dichotoma larva extract (ADLE) in a high-fat diet (HFD)-induced C57BL/6J mice model. Glucose tolerance and insulin sensitivity in HFD-induced diabetic mice significantly improved after ADLE administration for six weeks. The levels of serum triglyceride (TG), aspartate aminotransferase (AST), alanine transferase (ALT) activity, and lipid accumulation were increased in the liver of HFD-fed mice, but the levels were significantly reduced by the ADLE treatment. Moreover, hepatic fibrosis and inflammatory gene expression in the liver from HFD-treated mice were ameliorated by the ADLE treatment. Dephosphorylation of AMP-activated protein kinase (AMPK) by palmitate was inhibited in the ADLE treated HepG2 cells, and subsequently reduced expression of lipogenic genes, such as SREPBP-1c, ACC, and FAS were observed. The reduced expression of lipogenic genes and an increased phosphorylation of AMPK was also observed in the liver from diabetic mice treated with ADLE. In conclusion, ADLE ameliorates hyperlipidemia through inhibition of hepatic lipogenesis via activating the AMPK signaling pathway. These findings suggest that ADLE and its constituent bioactive compounds are valuable to prevent or treat hepatic insulin resistance in type 2 diabetes.en_US
dc.description.sponsorshipThis study was supported by the Basic Science Research Program grant (NRF-2018R1C1B6000998) provided by the National Research Foundation of Korea (NRF), which is funded by the Ministry of Science, ICT and Future Planning, Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health andWelfare, Republic of Korea (grant number: HI14C1135) and by a grant from Eulji University in 2019.en_US
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectAllomyrina dichotoma larvaen_US
dc.subjecthepatic insulin resistanceen_US
dc.subjectlipogenesisen_US
dc.titleAllomyrina dichotoma Larva Extract Ameliorates the Hepatic Insulin Resistance of High-Fat Diet-Induced Diabetic Miceen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume11-
dc.identifier.doi10.3390/nu11071522-
dc.relation.page1-14-
dc.relation.journalNUTRIENTS-
dc.contributor.googleauthorKim, Kyong-
dc.contributor.googleauthorBae, Gong Deuk-
dc.contributor.googleauthorLee, Minho-
dc.contributor.googleauthorPark, Eun-Young-
dc.contributor.googleauthorBaek, Dong Jae-
dc.contributor.googleauthorKim, Chul Young-
dc.contributor.googleauthorJun, Hee-Sook-
dc.contributor.googleauthorOh, Yoon Sin-
dc.relation.code2019044150-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidchulykim-


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