Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 주재범 | - |
dc.date.accessioned | 2019-12-04T05:18:14Z | - |
dc.date.available | 2019-12-04T05:18:14Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | SENSORS AND ACTUATORS B-CHEMICAL, v. 255, pt. 1, page. 183-192, Part:1 | en_US |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0925400517313552?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117192 | - |
dc.description.abstract | Surface-enhanced Raman scattering (SERS) has been of great interest to advance sensitive optical biosensors. Clustered metallic nanoparticles as SERS nanoprobes are important to detect specific biomolecules with ultra-sensitivity. We report herein that the cluster formation of gold nanoparticles (GNPs) was induced by nanoscale graphene oxides (NGOs) with 120 nm to develop a new class of SERS nanotags for biosensing. The GNPs with 4-mercaptopyridine as a Raman reporter were modified with 1-pyrenemethylamine to introduce hydrophobic moieties on the surfaces and were complexed with NGOs via noncovalent interactions of pi-pi stacking and van der Waals interactions, resulting in the formation of NGO-GNP clusters (NGO-GNPCs). The NGO-GNPCs increased the SERS signal 3- to 4-fold higher than that of the individual GNPs due to enhancement of the electromagnetic field at the interstices of the GNPs. As a proof of concept, the NGO-GNPCs as SERS nanoprobes and magnetic beads (MBs) were developed to detect immunoglobulin G (IgG). Sandwich-type immunocomplexes of the NGO-GNPCs, IgG, and MBs were formed, representing a linear correlation between Raman intensity and IgG concentration, and a limit of detection of 0.6 pM. It suggests that the NGO-GNPCs as SERS nanoprobes could open a new avenue for highly sensitive SERS-based biosensing. (C) 2017 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare, Korea (HI15C2958). The authors thank Hongdeok Jang for the work regarding the MNPs and their encapsulation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE SA | en_US |
dc.subject | Nanoscale graphene oxide | en_US |
dc.subject | Metallic nanoparticles | en_US |
dc.subject | Clusters | en_US |
dc.subject | Surface enhanced Raman scattering | en_US |
dc.subject | IgG detection | en_US |
dc.title | Nanoscale graphene oxide-induced metallic nanoparticle clustering for surface-enhanced Raman scattering-based IgG detection | en_US |
dc.type | Article | en_US |
dc.relation.volume | 255 | - |
dc.identifier.doi | 10.1016/j.snb.2017.07.140 | - |
dc.relation.page | 183-192 | - |
dc.relation.journal | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.contributor.googleauthor | Ali, Ahmed | - |
dc.contributor.googleauthor | Hwang, Eun Young | - |
dc.contributor.googleauthor | Choo, Jaebum | - |
dc.contributor.googleauthor | Lim, Dong Woo | - |
dc.relation.code | 2018001066 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | jbchoo | - |
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