Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-12-04T05:14:54Z | - |
dc.date.available | 2019-12-04T05:14:54Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | CELLULAR AND MOLECULAR BIOLOGY, v. 64, no. 1, page. 7-13 | en_US |
dc.identifier.issn | 0145-5680 | - |
dc.identifier.issn | 1165-158X | - |
dc.identifier.uri | https://www.cellmolbiol.org/index.php/CMB/article/view/1238 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117185 | - |
dc.description.abstract | This study aimed to evaluate the relationship between the level of 25-hydroxyvitamin D [25(OH)D] and systemic lupus erythematosus (SLE). We searched the PUBMED, EMBASE, and Cochrane databases and performed a meta-analysis examining the vitamin D level and/or deficiency in patients with SLE, compared with that in healthy controls. In total, 18 studies consisting of 1,083 patients with SLE and 1,273 controls were included. Vitamin D level was significantly lower in the SLE group than in the control group (standardized mean difference [SMD] = -0.938, 95% CI = -1.352 to -0.524, p = 9.0 x 10(-6)). Stratification by ethnicity showed a significantly decreased vitamin D level in the SLE group in the European and Arab populations (SMD = -1.485, 95% CI = -2.427 to -0.543, p = 0.002; SMD = -1.067, 95% CI = -1.251 to -0.883, p < 1.0 x 10(-8)), and an association tendency between decreased vitamin D level and SLE in the Asian population (SMD = -0.874, 95% CI = -2.073 to -0.324, p = 0.153). Subgroup analysis by sample size showed a significantly lower vitamin D level in the SLE group in small-(n = 100) and large-sample (n > 100) populations (SMD = -1.008, 95% CI = -1.672 to -0.344, p = 0.003; SMD = -0.863, 95% CI = -1.444 to -0.293, p = 0.003). Meta-analysis revealed a significant association between SLE and vitamin D deficiency (RR = 2.321, 95% CI = 1.361-3.960, p = 0.002). Stratification by ethnicity showed a significant association between SLE and vitamin D deficiency in European and Arab populations (RR = 2.182, 95% CI = 1.024-4.648, p = 0.043; RR = 4.550, 95% CI = 3.471-5.965, p < 1.0 x 10(-8)). Our meta-analysis demonstrates that compared with controls, patients with SLE show significantly low serum levels of vitamin D, and that a deficiency of vitamin D is associated with SLE. | en_US |
dc.description.sponsorship | This study was supported in part by NRF-2017M3A9B4050335, Republic of Korea. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | C M B ASSOC | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | Deficiency | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.title | Association between Vitamin D level and/or deficiency, and systemic lupus erythematosus: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 64 | - |
dc.identifier.doi | 10.14715/cmb/2018.64.1.2 | - |
dc.relation.page | 7-13 | - |
dc.relation.journal | CELLULAR AND MOLECULAR BIOLOGY | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.relation.code | 2018000564 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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