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Evaluation of Ganglion Cell-Inner Plexiform Layer Thinning in Eyes With Optic Disc Hemorrhage: A Trend-Based Progression Analysis

Title
Evaluation of Ganglion Cell-Inner Plexiform Layer Thinning in Eyes With Optic Disc Hemorrhage: A Trend-Based Progression Analysis
Author
이원준
Keywords
disc hemorrhage; ganglion cell-inner plexiform layer; optical coherence tomography; glaucoma; trend-based analysis
Issue Date
2017-12
Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
Citation
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v. 58, no. 14, page. 6449-6456
Abstract
PURPOSE. To evaluate the rate of change in ganglion cell-inner plexiform layer (GCIPL) thickness measured by optical coherence tomography (OCT) using a trend-based approach in early-stage glaucomatous eyes with disc hemorrhage (DH) and to compare the GCIPL thinning rate with that in glaucomatous eyes without DH.METHODS. This prospective observational study included 46 patients with early-stage open-angle glaucoma and DH who underwent serial spectral-domain OCT measurements for at least 30 months. The GCIPL thinning rate was determined in the global, superior, or inferior hemiretinas and in six macular sectors by linear regression and was compared between glaucomatous eyes with DH and fellow glaucomatous eyes without DH and between glaucomatous eyes with DH and non-DH glaucomatous control eyes.RESULTS. The GCIPL thinning rate (mean +/- standard deviation) was significantly more rapid in glaucomatous eyes with DH than in fellow eyes without DH in the inferior hemiretina (-1.07 +/- 0.75 vs. -0.44 +/- 0.54 mu m/y, P = 0.001), inferotemporal sector (-1.13 +/- 1.00 vs. -0.61 +/- 0.66 mu m/y, P = 0.028), and inferior sector (-1.33 +/- 0.79 vs. -0.42 +/- 0.78 mu m/y, P < 0.001). The GCIPL thinning rate was significantly more rapid in glaucomatous eyes with DH than in glaucomatous controls without DH in the global area (-0.78 +/- 0.85 vs. -0.32 +/- 0.48 mu m/y, P = 0.002), the inferior hemiretina (-1.00 +/- 0.94 vs. -0.37 +/- 0.67 mu m/y, P < 0.001), and the inferotemporal sector (-1.31 +/- 1.07 vs. -0.34 +/- 0.75 mu m/y, P < 0.001).CONCLUSIONS. The GCIPL thinning rate on OCT was significantly more rapid in glaucomatous eyes with DH than in fellow glaucomatous eyes without DH or glaucomatous control eyes without DH. DH could be associated with progression of glaucoma in terms of GCIPL thinning.
URI
https://iovs.arvojournals.org/article.aspx?articleid=2667224https://repository.hanyang.ac.kr/handle/20.500.11754/116896
ISSN
0146-0404; 1552-5783
DOI
10.1167/iovs.17-22547
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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