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Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus

Title
Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus
Author
배상철
Keywords
Systemic lupus erythematosus; Neuropsychiatric; Nucleosomes; Nitration
Issue Date
2017-12
Publisher
BIOMED CENTRAL LTD
Citation
ARTHRITIS RESEARCH & THERAPY, v. 19, Article no. 287
Abstract
Background: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE.Methods: We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort. This included 216 patients with NP events and two matched controls with SLE but no NP events for each of these patients. For the NP patients we tested samples taken before, during and after the NP event.Results: Twenty-six patients had events attributed to SLE according to the most stringent SLICC attribution rule. In these patients there was no association between onset of event and elevated serum NN. In 190 patients in whom events were not attributed to SLE by the SLICC rules, median serum NN was elevated at the onset of event (P = 0.006). The predominant clinical features in this group of 190 patients were headache, mood disorders and anxiety.Conclusions: Serum NN levels rise at the time of an NP event in a proportion of patients with SLE. Further studies are needed to determine the value of serum NN as a biomarker for NPSLE.
URI
https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1495-6https://repository.hanyang.ac.kr/handle/20.500.11754/116769
ISSN
1478-6354; 1478-6362
DOI
10.1186/s13075-017-1495-6
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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