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Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma

Title
Force-mediated proinvasive matrix remodeling driven by tumor-associated mesenchymal stem-like cells in glioblastoma
Author
서용준
Keywords
Actomyosin contractility; Glioblastoma; Proinvasive extracellular matrix remodeling; Tumor-associated mesenchymal stem-like cells
Issue Date
2017-12
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v. 51, no. 4, page. 182-187
Abstract
In carcinoma, cancer-associated fibroblasts participate in force-mediated extracellular matrix (ECM) remodeling, consequently leading to invasion of cancer cells. Likewise, the ECM remodeling actively occurs in glioblastoma (GBM) and the consequent microenvironmental stiffness is strongly linked to migration behavior of GBM cells. However, in GBM the stromal cells responsible for force-mediated ECM remodeling remain unidentified. We show that tumor-associated mesenchymal stem-like cells (tMSLCs) provide a preinvasive matrix condition in GBM by force-mediated ECM remodeling. Importantly, CCL2-mediated Janus kinase 1 (JAK1) activation increased phosphorylation of myosin light chain 2 in tMSLCs and led to collagen assembly and actomyosin contractility. Collectively, our findings implicate tMSLCs as stromal cells providing force-mediated preinvasive ECM remodeling in the GBM microenvironment, and reminiscent of fibroblasts in carcinoma.
URI
http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2018.51.4.185https://repository.hanyang.ac.kr/handle/20.500.11754/116758
ISSN
1976-6696; 1976-670X
DOI
10.5483/BMBRep.2018.51.4.185
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
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