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FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node

Title
FYN promotes mesenchymal phenotypes of basal type breast cancer cells through STAT5/NOTCH2 signaling node
Author
서용준
Keywords
MOLECULAR TARGETS; NOTCH; SRC; STAT5; THERAPY; CHEMOTHERAPY; TRANSDUCER; RECURRENCE; ACTIVATION; EXPRESSION
Issue Date
2017-12
Publisher
NATURE PUBLISHING GROUP
Citation
ONCOGENE, v. 37, no. 14, page. 1857-1868
Abstract
Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cancer subtype. Importantly, FYN enhanced NOTCH2 activation in basal type breast cancer cells through STAT5-mediated upregulation of Jagged-1 and DLL4 NOTCH ligands, thereby contributed to mesenchymal phenotypes. In addition, we found that high levels of FYN persist in basal type breast cancer cells by a positive feedback loop between FYN and STAT5. FYN interacted directly with STAT5 and increased p-STAT5 that further acts as a transcription factor for FYN. Taken together, our findings demonstrate a pivotal role of FYN and its downstream effectors in maintaining the basal type features in breast cancer.
URI
https://www.nature.com/articles/s41388-017-0114-yhttps://repository.hanyang.ac.kr/handle/20.500.11754/116741
ISSN
0950-9232; 1476-5594
DOI
10.1038/s41388-017-0114-y
Appears in Collections:
RESEARCH INSTITUTE[S](부설연구소) > THE RESEARCH INSTITUTE FOR NATURAL SCIENCES(자연과학연구소) > Articles
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