Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이동윤 | - |
dc.date.accessioned | 2019-12-03T03:44:33Z | - |
dc.date.available | 2019-12-03T03:44:33Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | SENSORS, v. 17, no. 12, Article no. 2840 | en_US |
dc.identifier.issn | 1424-8220 | - |
dc.identifier.uri | https://www.mdpi.com/1424-8220/17/12/2840 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/116736 | - |
dc.description.abstract | Despite high relevance of tear osmolarity and eye abnormality, numerous methods for detecting tear osmolarity rely upon expensive osmometers. We report a reliable method for simply determining sodium ion-based osmolarity in artificial tears using sequential DNAzymes. When sodium ion-specific DNAzyme and peroxidase-like DNAzyme were used as a sensing and detecting probe, respectively, the concentration of Na+ in artificial tears could be measured by absorbance or fluorescence intensity, which was highly correlated with osmolarity over the diagnostic range (R-2 > 0.98). Our approach is useful for studying eye diseases in relation to osmolarity. | en_US |
dc.description.sponsorship | This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2015M3A9E2030125). This work was also supported by Basic Science Research Program (No. 2012R1A6A1029029) through the NRF funded by the Ministry of Education. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI AG | en_US |
dc.subject | DNAzyme | en_US |
dc.subject | osmolarity | en_US |
dc.subject | sodium ion | en_US |
dc.subject | salinity | en_US |
dc.subject | tear | en_US |
dc.subject | dry eye | en_US |
dc.title | Facile determination of sodium ion and osmolarity in artificial tears by sequential DNAzymes | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 17 | - |
dc.identifier.doi | 10.3390/s17122840 | - |
dc.relation.page | 2840-2849 | - |
dc.relation.journal | SENSORS | - |
dc.contributor.googleauthor | Kim, Eun Hye | - |
dc.contributor.googleauthor | Lee, Eun-Song | - |
dc.contributor.googleauthor | Lee, Dong Yun | - |
dc.contributor.googleauthor | Kim, Young-Pil | - |
dc.relation.code | 2017007121 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | dongyunlee | - |
dc.identifier.orcid | http://orcid.org/0000-0001-7691-0447 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.