29 5

Iron homeostasis controls myeloid blood cell differentiation in Drosophila

Title
Iron homeostasis controls myeloid blood cell differentiation in Drosophila
Author
심지원
Keywords
blood; BPS; crystal cell; Drosophila; ferritin; Fer1HCH; FAC; hemocyte; intestine; iron; lymph gland; plasmatocyte
Issue Date
2017-12
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v. 40, no. 12, page. 976-985
Abstract
Iron is an essential divalent ion for aerobic life. Life has evolved to maintain iron homeostasis for normal cellular and physiological functions and therefore imbalances in iron levels exert a wide range of consequences. Responses to iron dysregulation in blood development, however, remain elusive. Here, we found that iron homeostasis is critical for differentiation of Drosophila blood cells in the larval hematopoietic organ, called the lymph gland. Supplementation of an iron chelator, bathophenanthroline disulfate (BPS) results in an excessive differentiation of the crystal cell in the lymph gland. This phenotype is recapitulated by loss of Fer1HCH in the intestine, indicating that reduced levels of systemic iron enhances crystal cell differentiation. Detailed analysis of Fer1HCH-taggedGFP revealed that Fer1HCH is also expressed in the hematopoietic systems. Lastly, blocking Fer1HCH expression in the mature blood cells showed marked increase in the blood differentiation of both crystal cells and plasmatocytes. Thus, our work suggests a relevance of systemic and local iron homeostasis in blood differentiation, prompting further investigation of molecular mechanisms underlying iron regulation and cell fate determination in the hematopoietic system.
URI
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2017.0287https://repository.hanyang.ac.kr/handle/20.500.11754/116493
ISSN
1016-8478; 0219-1032
DOI
10.14348/molcells.2017.0287
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
Files in This Item:
Iron homeostasis controls myeloid blood cell differentiation in Drosophila.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE