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dc.contributor.author양철수-
dc.date.accessioned2019-12-02T05:56:02Z-
dc.date.available2019-12-02T05:56:02Z-
dc.date.issued2017-11-
dc.identifier.citationJOURNAL OF MICROBIOLOGY, v. 55, no. 11, page. 909-917en_US
dc.identifier.issn1225-8873-
dc.identifier.issn1976-3794-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs12275-017-7392-5-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/116339-
dc.description.abstractDense granule protein-7 (GRA-7) is an excretory protein of Toxoplasma gondii. It is a potential serodiagnostic marker and vaccine candidate for toxoplasmosis. Previous reports demonstrated that GRA-7 induces innate immune responses in macrophages by interacting with TRAF6 via the MyD88-dependent pathway. In the present study, we evaluated the antiviral activity and induction of an antiviral state by GRA-7 both in vitro and in vivo. It was observed that GRA-7 markedly reduced the replication of vesicular stomatitis virus (VSV-GFP), influenza A virus (PR8-GFP), coxsackievirus (H3-GFP), herpes simplex virus (HSV-GFP), and adenovirus-GFP in epithelial (HEK293T/HeLa) and immune (RAW264.7) cells. These antiviral activities of GRA-7 were attributed to the induction of type I interferon (IFN) signaling, resulting in the secretion of IFNs and pro-inflammatory cytokines. Additionally, in BALB/c mice, intranasal administration of GRA-7 prevented lethal infection by influenza A virus (H1N1) and exhibited prophylactic effects against respiratory syncytial virus (RSV-GFP). Collectively, these results suggested that GRA-7 exhibits immunostimulatory and broad spectrum antiviral activities via type I IFN signaling. Thus, GRA-7 can be potentially used as a vaccine adjuvant or as a candidate drug with prophylactic potential against viruses.en_US
dc.description.sponsorshipThis work was supported by the Ministry for Food, Agriculture, Forestry, and Fisheries (Grant numbers 315044031 and 316043-3), Chungnam National University and the Korea Institute of Oriental Medicine by the Ministry of Education, Science, and Technology (MEST; Grant number K17281), Republic of Korea. The authors thank Dr. Y. K. Choi of the Chungbuk National University (Cheongju, Republic of Korea) for providing the challenge viruses.en_US
dc.language.isoen_USen_US
dc.publisherMICROBIOLOGICAL SOCIETY KOREAen_US
dc.subjectToxoplasma gondiien_US
dc.subjectGRA-7en_US
dc.subjectantiviral activityen_US
dc.titleDense Granule Protein-7 (GRA-7) of Toxoplasma gondii inhibits viral replication in vitro and in vivoen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s12275-017-7392-5-
dc.relation.page909-917-
dc.relation.journalJOURNAL OF MICROBIOLOGY-
dc.contributor.googleauthorWeeratunga, Prasanna-
dc.contributor.googleauthorHerath, Thilina U. B.-
dc.contributor.googleauthorKim, Tae-Hwan-
dc.contributor.googleauthorLee, Hyun-Cheol-
dc.contributor.googleauthorKim, Jae-Hoon-
dc.contributor.googleauthorLee, Byeong-Hoon-
dc.contributor.googleauthorLee, Eun-Seo-
dc.contributor.googleauthorChathuranga, Kiramage-
dc.contributor.googleauthorChathuranga, W. A. Gayan-
dc.contributor.googleauthorYang, Chul-Su-
dc.relation.code2017008723-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidchulsuyang-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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