Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤호주 | - |
dc.date.accessioned | 2019-12-01T17:44:45Z | - |
dc.date.available | 2019-12-01T17:44:45Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.citation | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v. 9, no. 6, page. 483-490 | en_US |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://e-aair.org/DOIx.php?id=10.4168/aair.2017.9.6.483 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/116056 | - |
dc.description.abstract | Purpose: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation. Methods: A uniform cluster analysis method was applied to 259 adult asthmatics who were regularly followed-up for over 1 year using 12 variables, selected on the basis of their contribution to asthma phenotypes. After clustering, clinical profiles and exacerbation rates during follow-up were compared among the clusters. Results: Four subphenotypes were identified: cluster 1 was comprised of patients with early-onset atopic asthma with preserved lung function, cluster 2 late-onset non-atopic asthma with impaired lung function, cluster 3 early-onset atopic asthma with severely impaired lung function, and cluster 4 late-onset non-atopic asthma with well-preserved lung function. The patients in clusters 2 and 3 were identified as exacerbation-prone asthmatics, showing a higher risk of asthma exacerbation. Conclusions: Two different phenotypes of exacerbation-prone asthma were identified among Korean asthmatics using cluster analysis; both were characterized by impaired lung function, but the age at asthma onset and atopic status were different between the two. | en_US |
dc.description.sponsorship | The study was supported by a research grant of Soonchunhyang University to Choon-Sik Park and by a grant of the Korean Health Technology Research and Development Project, Ministry of Health and Welfare, Republic of Korea (2014-ER7401-00). Clinical and laboratory data are provided from a biobank of Soonchunhyang University Bucheon Hospital. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY | en_US |
dc.subject | Asthma | en_US |
dc.subject | cluster analysis | en_US |
dc.subject | exacerbation | en_US |
dc.title | Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.4168/aair.2017.9.6.483 | - |
dc.relation.page | 483-490 | - |
dc.relation.journal | ALLERGY ASTHMA & IMMUNOLOGY RESEARCH | - |
dc.contributor.googleauthor | Kim, Mi-Ae | - |
dc.contributor.googleauthor | Shin, Seung-Woo | - |
dc.contributor.googleauthor | Park, Jong-Sook | - |
dc.contributor.googleauthor | Uh, Soo-Taek | - |
dc.contributor.googleauthor | Chang, Hun Soo | - |
dc.contributor.googleauthor | Bae, Da-Jeong | - |
dc.contributor.googleauthor | Cho, You Sook | - |
dc.contributor.googleauthor | Park, Hae-Sim | - |
dc.contributor.googleauthor | Yoon, Ho Joo | - |
dc.contributor.googleauthor | Choi, Byoung Whui | - |
dc.relation.code | 2017011921 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hjyoon | - |
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