167 123

Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis

Title
Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis
Author
윤호주
Keywords
Asthma; cluster analysis; exacerbation
Issue Date
2017-11
Publisher
KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
Citation
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v. 9, no. 6, page. 483-490
Abstract
Purpose: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation. Methods: A uniform cluster analysis method was applied to 259 adult asthmatics who were regularly followed-up for over 1 year using 12 variables, selected on the basis of their contribution to asthma phenotypes. After clustering, clinical profiles and exacerbation rates during follow-up were compared among the clusters. Results: Four subphenotypes were identified: cluster 1 was comprised of patients with early-onset atopic asthma with preserved lung function, cluster 2 late-onset non-atopic asthma with impaired lung function, cluster 3 early-onset atopic asthma with severely impaired lung function, and cluster 4 late-onset non-atopic asthma with well-preserved lung function. The patients in clusters 2 and 3 were identified as exacerbation-prone asthmatics, showing a higher risk of asthma exacerbation. Conclusions: Two different phenotypes of exacerbation-prone asthma were identified among Korean asthmatics using cluster analysis; both were characterized by impaired lung function, but the age at asthma onset and atopic status were different between the two.
URI
https://e-aair.org/DOIx.php?id=10.4168/aair.2017.9.6.483https://repository.hanyang.ac.kr/handle/20.500.11754/116056
ISSN
2092-7355; 2092-7363
DOI
10.4168/aair.2017.9.6.483
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
Clinical Characteristics of Exacerbation-Prone Adult Asthmatics Identified by Cluster Analysis.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE