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Prognostic role of copeptin after traumatic brain injury: A systematic review and meta-analysis of observational studies

Title
Prognostic role of copeptin after traumatic brain injury: A systematic review and meta-analysis of observational studies
Author
이형중
Keywords
Traumatic brain injury; Copeptin; Meta-analysis; Prognosis
Issue Date
2017-10
Publisher
W B SAUNDERS CO-ELSEVIER INC
Citation
AMERICAN JOURNAL OF EMERGENCY MEDICINE, v. 35, no. 10, page. 1444-1450
Abstract
Purpose: Copeptin, the C-terminal portion of provasopressin, has emerged as a novel prognostic marker in neurocritical care, such as in traumatic brain injury (TBI). The aim of this study was to quantitatively assess the prognostic significance of initial plasma copeptin levels in the neurological outcome and mortality after traumatic brain injury. Materials and methods: Six relevant studies with data from 552 patients were included in this meta-analysis. Results: The plasma copeptin levels were found to be significantly higher in patients who died than in the survivors (standardized mean difference [SMD], 1.80). In the four studies reporting Glasgow outcome scale (GOS) data, patients with unfavorable outcomes had significantly higher copeptin levels than those with favorable outcomes (SMD, 1.62). The plasma copeptin level predicted mortality and unfavorable outcomes (AUC, 0.873; AUC, 0.876). Conclusions: The present meta-analysis suggests that early measurement of plasma copeptin levels can provide better prognostic information about the functional outcome and mortality in patients with TBI. (C) 2017 Elsevier Inc. All rights reserved.
URI
https://www.ajemjournal.com/article/S0735-6757(17)30302-9/fulltexthttps://repository.hanyang.ac.kr/handle/20.500.11754/115962
ISSN
0735-6757; 1532-8171
DOI
10.1016/j.ajem.2017.04.038
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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