Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2019-12-01T14:52:18Z | - |
dc.date.available | 2019-12-01T14:52:18Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.citation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v. 76, no. 8, page. 708-715 | en_US |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.issn | 1435-1250 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00393-016-0157-4 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/115941 | - |
dc.description.abstract | Objective. The aim of this study was to determine whether endothelial nitric oxide synthase (eNOS) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Methods. A meta-analysis was conducted on associations between the 4b/a, T786C, and G894T polymorphisms of eNOS and SLE or RA using the following methods: (1) allele contrast, (2) recessive model, (3) dominant model, and (4) homozygous contrast.Results. Nineteen studies were included in this meta-analysis, comprising eleven studies on SLE (1561 patients and 1565 controls) and eight on RA (1624 patients and 2118 controls). Meta-analysis showed a significant association between SLE and the 4b/a polymorphism using the recessivemodel and the homozygous contrast (odds ratio [OR] = 1.836, 95% confidence interval [CI] = 1.171-2.878, p = 0.008; OR = 2.055, 95% CI = 1.302-3.243, p = 0.002). Ethnicity-specific meta-analysis showed a significant association between the aa vs. bb of the 4b/a polymorphism and SLE in European populations (OR = 2.096, 95% CI = 1.288-4.0, p = 0.027), but not in Arab populations. Stratification by presence of lupus nephritis (LN) indicated a significant association between the a allele and the aa + ab genotype of the 4b/a polymorphismand LN in SLE patients (OR = 2.125, 95% CI = 1.289-3.054, p = 0.003; OR = 2.655, 95% CI = 1.509-4.671, p = 0.001). Meta-analysis indicated no association between SLE and the T786C and G894T polymorphisms. No association was found between the eNOS 4b/a, T786C, and G894T polymorphisms and RAConclusions. This meta-analysis of published studies shows that the eNOS 4b/a polymorphism may be associated with the development of SLE, but the 4b/a, T786C, and G894T polymorphismsmay be not associated with RA susceptibility. | en_US |
dc.description.sponsorship | This study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPRINGER HEIDELBERG | en_US |
dc.subject | Systemic lupus erythematosus | en_US |
dc.subject | Rheumatoid arthritis | en_US |
dc.subject | Endothelial nitric oxide synthase | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Meta-analysis | en_US |
dc.title | Associations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.no | 8 | - |
dc.relation.volume | 76 | - |
dc.identifier.doi | 10.1007/s00393-016-0157-4 | - |
dc.relation.page | 708-715 | - |
dc.relation.journal | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.contributor.googleauthor | Lee, Y. H. | - |
dc.contributor.googleauthor | Bae, S. -C. | - |
dc.relation.code | 2017001394 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
dc.identifier.orcid | http://orcid.org/0000-0003-4658-1093 | - |
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