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dc.contributor.author배상철-
dc.date.accessioned2019-12-01T14:52:18Z-
dc.date.available2019-12-01T14:52:18Z-
dc.date.issued2017-10-
dc.identifier.citationZEITSCHRIFT FUR RHEUMATOLOGIE, v. 76, no. 8, page. 708-715en_US
dc.identifier.issn0340-1855-
dc.identifier.issn1435-1250-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00393-016-0157-4-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/115941-
dc.description.abstractObjective. The aim of this study was to determine whether endothelial nitric oxide synthase (eNOS) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Methods. A meta-analysis was conducted on associations between the 4b/a, T786C, and G894T polymorphisms of eNOS and SLE or RA using the following methods: (1) allele contrast, (2) recessive model, (3) dominant model, and (4) homozygous contrast.Results. Nineteen studies were included in this meta-analysis, comprising eleven studies on SLE (1561 patients and 1565 controls) and eight on RA (1624 patients and 2118 controls). Meta-analysis showed a significant association between SLE and the 4b/a polymorphism using the recessivemodel and the homozygous contrast (odds ratio [OR] = 1.836, 95% confidence interval [CI] = 1.171-2.878, p = 0.008; OR = 2.055, 95% CI = 1.302-3.243, p = 0.002). Ethnicity-specific meta-analysis showed a significant association between the aa vs. bb of the 4b/a polymorphism and SLE in European populations (OR = 2.096, 95% CI = 1.288-4.0, p = 0.027), but not in Arab populations. Stratification by presence of lupus nephritis (LN) indicated a significant association between the a allele and the aa + ab genotype of the 4b/a polymorphismand LN in SLE patients (OR = 2.125, 95% CI = 1.289-3.054, p = 0.003; OR = 2.655, 95% CI = 1.509-4.671, p = 0.001). Meta-analysis indicated no association between SLE and the T786C and G894T polymorphisms. No association was found between the eNOS 4b/a, T786C, and G894T polymorphisms and RAConclusions. This meta-analysis of published studies shows that the eNOS 4b/a polymorphism may be associated with the development of SLE, but the 4b/a, T786C, and G894T polymorphismsmay be not associated with RA susceptibility.en_US
dc.description.sponsorshipThis study was supported in part by a grant of the Korea Healthcare technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958).en_US
dc.language.isoen_USen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.subjectSystemic lupus erythematosusen_US
dc.subjectRheumatoid arthritisen_US
dc.subjectEndothelial nitric oxide synthaseen_US
dc.subjectPolymorphismen_US
dc.subjectMeta-analysisen_US
dc.titleAssociations between eNOS polymorphisms and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: a meta-analysisen_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume76-
dc.identifier.doi10.1007/s00393-016-0157-4-
dc.relation.page708-715-
dc.relation.journalZEITSCHRIFT FUR RHEUMATOLOGIE-
dc.contributor.googleauthorLee, Y. H.-
dc.contributor.googleauthorBae, S. -C.-
dc.relation.code2017001394-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
dc.identifier.orcidhttp://orcid.org/0000-0003-4658-1093-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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